Alzheimer's disease represents the most prevalent neurodegeneration worldwide, clinically characterized by cognitive and memory impairment. New therapeutic approaches are extremely important to counteract this disorder. This research is focused on the potential use of choline alfoscerate in preventing neuronal death using in vitro models of Alzheimer's disease, representing the early stage of the disease, treated before or after the insult with glycerylphosphorylcholine. On the light of the results collected, we can postulate that choline alfoscerate, by the activation of the neurotrophin survival pathway, was able to counteract the detrimental effect of β‐amyloid in both in vitro models, reducing apoptotic cell death and preserving the neuronal morphology.

中文翻译：

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fo药胆碱对β-淀粉样蛋白损伤的神经保护潜力：涉及神经营养信号。

阿尔茨海默氏病是全球最普遍的神经退行性疾病，临床上以认知和记忆障碍为特征。新的治疗方法对抵抗这种疾病极为重要。这项研究的重点是利用阿尔茨海默氏病的体外模型（代表该疾病的早期阶段）在用甘油基磷酰胆碱治疗之前或之后进行治疗，从而可以有效地利用磷胆碱来预防神经元死亡。根据收集到的结果，我们可以推测，通过激活神经营养蛋白的生存途径，阿魏酸胆碱能够抵消β-淀粉样蛋白在两种体外模型中的有害作用，从而减少凋亡细胞的死亡并保持神经元形态。 。