This study examined sensitivity of eye tracking measures to hyperphagia severity in Prader‐Willi syndrome (PWS). Gaze data were collected in 57 children with PWS, age 3–11 years, and 47 typically developing peers at two study sites during free visual exploration of complex stimulus arrays that included images of food, animals, and household objects. Analysis of the number and duration of fixations as well as gaze perseverations revealed that food items are not exceptionally salient for children with PWS. Instead, increased attention to food in the context of other high‐interest items (e.g., animals) was associated with caregiver reports of more severe hyperphagia and more advanced nutritional phase. The study also provided preliminary evidence of possible genetic subtype and sex differences as well as demonstrated that multiple investigators in a wide range of settings can effectively implement the eye tracking protocol. The results indicate that gaze characteristics derived from eye tracking may be a promising objective marker of hyperphagia in PWS for use in research and clinical trials.

中文翻译：

---

眼动追踪作为普瑞德威利综合征儿童吞食过多的客观测量。


本研究检查了眼动追踪测量对普瑞德-威利综合征 (PWS) 吞咽过多严重程度的敏感性。研究人员在两个研究地点收集了 57 名 3-11 岁 PWS 儿童和 47 名正常发育同龄人在对复杂刺激阵列（包括食物、动物和家用物品的图像）进行自由视觉探索期间的注视数据。对注视次数和持续时间以及凝视持续时间的分析表明，食物对于 PWS 儿童来说并不是特别重要。相反，在其他高兴趣项目（例如动物）的背景下对食物的更多关注与护理人员报告的更严重的进食过多和更高级的营养阶段有关。该研究还提供了可能的遗传亚型和性别差异的初步证据，并证明了多个研究人员在广泛的环境中可以有效地实施眼动追踪协议。结果表明，来自眼球追踪的注视特征可能是 PWS 吞食过多的一个有希望的客观标志，可用于研究和临床试验。