Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients. This review focuses on the expression and activation of CREB under physiologic conditions and in tumors of distinct origin as well as the underlying mechanisms of CREB regulation by diverse stimuli and inhibitors. In addition, the clinical relevance of CREB is summarized, including its use as a prognostic and/or predictive marker as well as a therapeutic target.

中文翻译：

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是什么开启了 CREB？然后关闭？为什么这很重要？


转录因子环AMP反应结合蛋白（CREB）的表达和功能的改变已被确定在癌症中发挥重要作用，并且与肿瘤患者的总体生存和治疗反应相关。本综述重点关注生理条件下和不同来源肿瘤中 CREB ​​的表达和激活，以及不同刺激和抑制剂调节 CREB ​​的潜在机制。此外，还总结了 CREB ​​的临床相关性，包括其作为预后和/或预测标记物以及治疗靶点的用途。