Studies of the labile lead pool using a rhodamine-based fluorescent probe.,Metallomics

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Studies of the labile lead pool using a rhodamine-based fluorescent probe.
Metallomics ( IF 2.9 ) Pub Date : 2020-04-28 , DOI: 10.1039/d0mt00056f
Jianping Zhu ₁ , Jia Hao Yeo , Amy A Bowyer , Nicholas Proschogo , Elizabeth J New

Affiliation

Lead is a heavy metal which has long been known to have toxic effects on the body. However, much remains to be learnt about the labile lead pool and cellular uptake of lead. We report here RPb1 that undergoes a 100-fold increase in fluorescence emission in the presence of Pb2+, and which can be applied to study the labile lead pool within cells. We demonstrate the capacity of RPb1 for investigating labile lead pool in DLD-1 cells and changes in labile lead during differentiation of K562 cells.

中文翻译：

使用基于若丹明的荧光探针研究不稳定的铅库。

铅是一种重金属，长期以来对人体有毒作用。但是，关于不稳定的铅库和细胞对铅的吸收，仍有许多知识要学习。我们在这里报告RPb1在Pb2 +存在下经历了100倍的荧光发射增加，可用于研究细胞内不稳定的铅库。我们证明了RPb1在DLD-1细胞中研究不稳定铅库和在K562细胞分化过程中不稳定铅的变化的能力。

更新日期：2020-04-28

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