During meiosis, nuclear events and meiotic progression are tightly coordinated, an essential and systemic requirement for the production of haploid gametes. In mammalian male meiosis, meiotic prophase I (PI) comprises a lengthy period of germ cell development that, upon completion, transitions into meiotic metaphase I (MI). While the PI/MI transition corresponds to the mitotic cell cycle’s G2/M transition, it remains unknown how nuclear events in PI license entry into MI. A recent study by Guan et al. demonstrates that SKP1, a core subunit of the Skp1, Cullin, F-box (SCF) complex, confers competence for the PI/MI transition [1]. SCF, an E3 ubiquitin ligase and well-known cell cycle regulator, enables the mitotic cell cycle through ubiquitin–proteasome-dependent degradation of cell cycle factors [2, 3]. Having revealed novel meiotic functions for SCF, Guan et al. offer clues to understand the mechanistic similarities and differences between the meiotic PI/MI transition and the mitotic G2/M transition.

中文翻译：

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许可减数分裂进展†。

在减数分裂期间，核事件和减数分裂进程紧密协调，这是产生单倍体配子的基本和系统要求。在哺乳动物雄性减数分裂中，减数分裂前期 I (PI) 包括一个漫长的生殖细胞发育期，完成后过渡到减数分裂中期 I (MI)。虽然 PI/MI 转换对应于有丝分裂细胞周期的 G2/M 转换，但仍不清楚 PI 许可中的核事件如何进入 MI。关等人最近的一项研究。证明 SKP1 是 Skp1、Cullin、F-box (SCF) 复合体的核心亚基，赋予 PI/MI 过渡能力 [1]。SCF 是一种 E3 泛素连接酶和众所周知的细胞周期调节剂，通过泛素-蛋白酶体依赖性细胞周期因子降解来启动有丝分裂细胞周期 [2, 3]。Guan 等人揭示了 SCF 的新减数分裂功能。提供线索以了解减数分裂 PI/MI 过渡和有丝分裂 G2/M 过渡之间的机制异同。