COVID-19 vaccine design: the Janus face of immune enhancement.,Nature Reviews Immunology

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COVID-19 vaccine design: the Janus face of immune enhancement.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2020-04-28 , DOI: 10.1038/s41577-020-0323-4
Peter J Hotez _{1,

2,

3,

4} , David B Corry _{5,

6} , Maria Elena Bottazzi _{1,

2,

3}

Affiliation

Previous work on severe acute respiratory syndrome coronavirus (SARS-CoV) vaccines identified cellular immunopathology and antibody-dependent enhancement as potential safety issues. We discuss the implications of these findings for COVID-19 vaccine development and our approach to optimizing for safety and efficacy. Here, Hotez and colleagues highlight the two ‘faces’ of immune enhancement that could impact COVID-19 vaccine design.

中文翻译：

COVID-19 疫苗设计：免疫增强的 Janus 面孔。

先前关于严重急性呼吸综合征冠状病毒 (SARS-CoV) 疫苗的工作将细胞免疫病理学和抗体依赖性增强确定为潜在的安全问题。我们讨论了这些发现对 COVID-19 疫苗开发的影响以及我们优化安全性和有效性的方法。在这里，Hotez 及其同事强调了可能影响 COVID-19 疫苗设计的免疫增强的两个“面”。

更新日期：2020-04-28

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