Epigenetic manipulation of host cells by intracellular pathogens has become increasingly evident. Lecoeur et al. show us how Leishmania amazonensis inhibits macrophage inflammasomes by modifying histone H3 activation marks on NF-κB-associated gene promoters that increase the expression of inhibitors and downmodulates activators of this pathway.

中文翻译：

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利什曼原虫：巨噬细胞炎性体表观遗传操纵的大师。

细胞内病原体对宿主细胞的表观遗传操纵已变得越来越明显。Lecoeur等。向我们展示了利什曼原虫如何通过修饰NF-κB相关基因启动子上的组蛋白H3激活标记来抑制巨噬细胞炎性体，从而增加该抑制剂的表达并下调该途径的激活剂。