A series of non-annulated products: trifluoromethylpyrazolone-tethered trisubstituted methane derivatives were synthesized in high yields in acetonitrile solvent catalyzed by NH₄OAc via one-pot, three-component reactions of 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes and 1-aryl-3-trifluoromethyl-5-pyrazolone. Treatment of trifluoromethylpyrazolone-tethered trisubstituted methane derivatives with the dehydrating agent SOCl₂/Pyridine in acetonitrile afforded the corresponding annulated fused polyheterocyclic products trifluoromethylated benzo[6,7]chromeno[2,3-c]pyrazole-5,10-dione derivatives. Furthermore, an efficient, straightforward protocol has been developed for the synthesis of trifluoromethylated benzo[6,7]chromeno[2,3-c]pyrazole-5,10-dione derivatives at medium yields via one-pot, two-step, three-component reactions. Meanwhile, the structures of typical products were further confirmed by XRD-analysis.

通过NH ₄ OAc催化的2-羟基-1,4-萘醌，芳香醛和三元醇的一锅，三组分反应，在乙腈溶剂中高收率合成了一系列非环状产物：三氟甲基吡唑啉酮系链的三取代甲烷衍生物。1-芳基-3-三氟甲基-5-吡唑酮。用脱水剂SOCl ₂ /吡啶在乙腈中处理三氟甲基吡唑啉酮连接的三取代甲烷衍生物，得到相应的环合稠合多杂环产物，三氟甲基化苯并[6,7] chromeno [2,3 - c ]吡唑-5,10-二酮衍生物。此外，已经开发了一种有效，简单的方法来合成三氟甲基化的苯并[6,7]铬[2,3- c一锅，两步，三组分反应以中等收率得到]吡唑-5,10-二酮衍生物。同时，通过XRD分析进一步证实了典型产品的结构。