Stem cell research has progressed widely and has been receiving a considerable attention for its advantages and drawbacks. Despite their extensive therapeutic potential in regenerative medicine, they are debatable for their genetic and epigenetic stability. In fact lineage specific differentiation is mediated via epigenetic changes in DNA methylation, acetylation, histone modifications etc. Thus epigenetics plays an important role in stem cell biology. For therapeutic interventions stem cells need to be genetically and epigenetically stable for their maximum paracrine secretions for bringing about expected tissue repair and regeneration. In this review we have focused on the current status of genetic and epigenetic stability in stem cells and their importance in regenerative medicine. We have also touched upon the possibility of considering tissue resident mesenchymal stem cells as epigenetic modifiers. This is likely to open a new era in stem cell therapeutic intervention by reversing disease inducing epigenetic changes.

中文翻译：

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干细胞的遗传和表观遗传稳定性：表观遗传修饰剂调节间充质干细胞的命运。

干细胞研究取得了广泛进展，并因其优点和缺点而受到相当多的关注。尽管它们在再生医学中具有广泛的治疗潜力，但它们的遗传和表观遗传稳定性仍存在争议。事实上，谱系特异性分化是通过 DNA 甲基化、乙酰化、组蛋白修饰等的表观遗传变化介导的。因此表观遗传学在干细胞生物学中起着重要作用。对于治疗干预，干细胞需要在遗传和表观遗传上保持稳定，以产生最大的旁分泌物，以实现预期的组织修复和再生。在这篇综述中，我们重点介绍了干细胞中遗传和表观遗传稳定性的现状及其在再生医学中的重要性。我们还谈到了将组织驻留间充质干细胞作为表观遗传修饰剂的可能性。通过逆转引起表观遗传变化的疾病，这可能会开启干细胞治疗干预的新时代。