The aggregation and cellular mislocalization of several RNA-binding proteins (RBPs) have been identified as the major hallmarks of neurodegenerative diseases such as frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). However, it remains obscure whether these pathological changes also occur during cerebral ischemia. In this study, we report that RBPs increased significantly compared with the sham group (*p < 0.05 and **p < 0.01 vs sham), with nuclear depletion and cytoplasmic deposition in neurons in the acute phase of cerebral ischemia. On the other hand, such nucleocytoplasmic mislocalization were not observed in astrocytes. We provide evidence of the alteration of these neurodegeneration-related RBPs after cerebral ischemia, suggesting a potential association between cerebral ischemia and neurodegenerative diseases.

中文翻译：

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小鼠中风模型中神经退行性疾病相关蛋白的动态变化和错误定位。

几种 RNA 结合蛋白 (RBP) 的聚集和细胞错误定位已被确定为神经退行性疾病的主要标志，如额颞叶痴呆 (FTD) 和肌萎缩侧索硬化 (ALS)。然而，这些病理变化是否也发生在脑缺血期间仍不清楚。在这项研究中，我们报告说与假手术组相比，RBP 显着增加（*p < 0.05 和 **p < 0.01 vs 假手术），在脑缺血急性期，神经元核耗竭和细胞质沉积。另一方面，在星形胶质细胞中没有观察到这种核质错误定位。我们提供了脑缺血后这些神经变性相关 RBP 改变的证据，表明脑缺血与神经退行性疾病之间存在潜在关联。