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Microbiota Metabolites in Health and Disease
Annual Review of Immunology ( IF 26.9 ) Pub Date : 2020-04-27
Justin L. McCarville, Grischa Y. Chen, Víctor D. Cuevas, Katia Troha, Janelle S. Ayres

Metabolism is one of the strongest drivers of interkingdom interactions—including those between microorganisms and their multicellular hosts. Traditionally thought to fuel energy requirements and provide building blocks for biosynthetic pathways, metabolism is now appreciated for its role in providing metabolites, small-molecule intermediates generated from metabolic processes, to perform various regulatory functions to mediate symbiotic relationships between microbes and their hosts. Here, we review recent advances in our mechanistic understanding of how microbiota-derived metabolites orchestrate and support physiological responses in the host, including immunity, inflammation, defense against infections, and metabolism. Understanding how microbes metabolically communicate with their hosts will provide us an opportunity to better describe how a host interacts with all microbes—beneficial, pathogenic, and commensal—and an opportunity to discover new ways to treat microbial-driven diseases.

中文翻译:


卫生与疾病中的微生物群代谢产物

代谢是相互作用的最强驱动力之一,包括微生物与其多细胞宿主之间的相互作用。传统上认为代谢能增加能量需求并为生物合成途径提供基础,如今,新陈代谢因其在提供代谢产物,代谢过程中产生的小分子中间体,执行各种调节功能以介导微生物与其宿主之间的共生关系方面的作用而受到赞赏。在这里,我们回顾了有关微生物来源的代谢物如何协调和支持宿主体内生理反应(包括免疫力,炎症,防御感染和新陈代谢)的机制理解的最新进展。

更新日期:2020-04-27
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