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The Emerging Role of B Lymphocytes in Cardiovascular Disease
Annual Review of Immunology ( IF 26.9 ) Pub Date : 2020-04-27
Luigi Adamo, Cibele Rocha-Resende, Douglas L. Mann

B cells are traditionally known for their ability to produce antibodies in the context of adaptive immune responses. However, over the last decade B cells have been increasingly recognized as modulators of both adaptive and innate immune responses, as well as players in an important role in the pathogenesis of a variety of human diseases. Here, after briefly summarizing our current understanding of B cell biology, we present a systematic review of the literature from both animal models and human studies that highlight the important role that B lymphocytes play in cardiac and vascular disease. While many aspects of B cell biology in the vasculature and, to an even greater extent, in the heart remain unclear, B cells are emerging as key regulators of cardiovascular adaptation to injury.

中文翻译:


B淋巴细胞在心血管疾病中的新兴作用

传统上,B细胞在适应性免疫反应中具有产生抗体的能力。然而,在过去的十年中,B细胞已被越来越多地认为是适应性免疫反应和先天性免疫反应的调节剂,并且在多种人类疾病的发病机理中起着重要作用。在这里,在简要总结了我们目前对B细胞生物学的理解之后,我们对来自动物模型和人体研究的文献进行了系统的综述,突出了B淋巴细胞在心脏和血管疾病中的重要作用。虽然尚不清楚脉管系统中以及甚至更大程度上心脏中B细胞生物学的许多方面,但B细胞正在成为心血管适应损伤的关键调节剂。

更新日期:2020-04-27
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