Stem cell aging contributes to aging-associated tissue degeneration and dysfunction. Recent studies reveal a mitochondrial metabolic checkpoint that regulates stem cell quiescence and maintenance, and dysregulation of the checkpoint leads to functional deterioration of aged stem cells. Here, we present the evidence supporting the mitochondrial metabolic checkpoint regulating stem cell aging and demonstrating the feasibility to target this checkpoint to reverse stem cell aging. We discuss the mechanisms by which mitochondrial stress leads to stem cell deterioration. We speculate the therapeutic potential of targeting the mitochondrial metabolic checkpoint for rejuvenating aged stem cells and improving aging tissue functions.

中文翻译：

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干细胞衰老和再生中的线粒体代谢检查点。

干细胞衰老会导致与衰老相关的组织退化和功能障碍。最近的研究揭示了调节干细胞静止和维持的线粒体代谢检查点，检查点的失调导致老化干细胞的功能恶化。在这里，我们提供了支持线粒体代谢检查点调节干细胞衰老的证据，并证明了靶向该检查点以逆转干细胞衰老的可行性。我们讨论了线粒体应激导致干细胞退化的机制。我们推测靶向线粒体代谢检查点以恢复衰老干细胞和改善衰老组织功能的治疗潜力。