Since the identification of the mitochondrial calcium uniporter (MCU) in 2011, several studies utilizing genetic models have attempted to decipher the role of mitochondrial calcium uptake in cardiac physiology. Confounding results in various mutant mouse models have led to an ongoing debate regarding the function of MCU in the heart. In this review, we evaluate and discuss the totality of evidence for mitochondrial calcium uptake in the cardiac stress response and highlight recent reports that implicate MCU in the control of homeostatic cardiac metabolism and function. This review concludes with a discussion of current gaps in knowledge and remaining experiments to define how MCU contributes to contractile function, cell death, metabolic regulation, and heart failure progression.

中文翻译：

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辩论仍在继续-心脏中MCU和线粒体钙摄取的作用是什么？

自2011年确定线粒体钙单向转运蛋白（MCU）以来，利用遗传模型进行的多项研究试图破译线粒体钙摄取在心脏生理中的作用。各种突变小鼠模型中令人困惑的结果导致有关心脏中MCU功能的争论不断。在这篇综述中，我们评估和讨论了心脏应激反应中线粒体钙摄取的证据，并重点介绍了最近报道表明MCU可以控制心脏稳态代谢和功能。本文以对当前知识差距和剩余实验的讨论作为结束，以定义MCU如何促进收缩功能，细胞死亡，代谢调节和心力衰竭进展。