Supra-coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion.,Acta Physiologica

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Supra-coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion.
Acta Physiologica ( IF 6.3 ) Pub Date : 2020-04-27 , DOI: 10.1111/apha.13483
Lian Tian ₁ , Ping Yu Xiong _{1,

2} , Elahe Alizadeh ₃ , Patricia D A Lima ₃ , François Potus ₁ , Jeffrey Mewburn ₁ , Ashley Martin ₁ , Kuang-Hueih Chen ₁ , Stephen L Archer _{1,

3}

Affiliation

Pulmonary arterial hypertension (PAH) results in right ventricular (RV) dysfunction owing, in part, to RV ischemia. The relative contribution of RV microvascular rarefaction vs reduced right coronary artery perfusion pressure (RCA‐PP) to RV ischemia remains unknown. We hypothesize that increasing RCA‐PP improves RV function in PAH by increasing RV systolic perfusion.

中文翻译：

冠状动脉上带通过增加收缩期右冠状动脉灌注来改善实验性肺动脉高压大鼠的右心室功能。

肺动脉高压 (PAH) 导致右心室 (RV) 功能障碍，部分原因是 RV 缺血。RV 微血管稀疏与降低的右冠状动脉灌注压 (RCA-PP) 对 RV 缺血的相对贡献仍然未知。我们假设增加 RCA-PP 通过增加 RV 收缩灌注来改善 PAH 中的 RV 功能。

更新日期：2020-04-27

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