The irradiation of tumors in radiotherapy requires accurate 3D dosimetry. The Fricke 3D dosimeters, which were considered to be high potential of application in 3D dosimetry, suffer from a reduced temporal integrity of dose distribution caused by Fe³⁺ ions diffusion. To overcome the drawback, we firstly synthesized a kind of amphiphilic molecules with critical micelle concentration of 0.45 g/L and hydrophile‐lipophile balance value of 10, then prepared multiple emulsions by self‐assembling those molecules in Fricke solution under liquid paraffin, and finally obtained Fricke hydrogel embedded with the multiple emulsions. The diffusion coefficient of Fe³⁺ ions in the embedded Fricke hydrogel was measured to be 0.17 mm²/h. The hydrogel dosimeter exhibits considerable potential for use in dose verification applications.

中文翻译：

---

制备W1 / O / W2乳液以限制Fe3 +在Fricke凝胶3D剂量计中的扩散

放射治疗中的肿瘤照射需要精确的3D剂量测定法。Fricke 3D剂量计被认为在3D剂量测定中具有很高的应用潜力，但由于Fe ³⁺离子扩散而导致剂量分布的时间完整性降低。为了克服这一缺点，我们首先合成了一种临界胶束浓度为0.45 g / L，亲水亲脂平衡值为10的两亲分子，然后通过在液体石蜡下在Fricke溶液中自组装这些分子来制备多种乳液，最后获得嵌入有多种乳液的Fricke水凝胶。Fe ³⁺离子在包埋的Fricke水凝胶中的扩散系数经测量为0.17 mm ²/H。水凝胶剂量计具有用于剂量验证应用的巨大潜力。