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121st Meeting of the British Neuropathological Society UCL Great Ormond Street Institute of Child Health, London
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2020-02-18 , DOI: 10.1111/nan.12603
中文翻译:
英国神经病理学会UCL英国大奥蒙德街儿童健康研究所第121届会议,伦敦
更新日期:2020-02-18
Neuropathology and Applied Neurobiology ( IF 4.0 ) Pub Date : 2020-02-18 , DOI: 10.1111/nan.12603
Symposium Wednesday 4th March 2020
Neurodegeneration: The prion‐like properties of mis‐folded proteins in neurodegenerative diseases
Chairs: Professor Tiago Outeiro, Newcastle University, Newcastle, UK and University Medical Center Goettingen, Goettingen, Germany | ||
Dr Tammaryn Lashley, Principal Research Fellow Neurodegenerative Diseases, Director of Research Queen Square Brain Bank, UCL Queen Square Institute of Neurology, London, UK | ||
12:00 | Registration | |
12:50 | Welcome and Introduction Tiago Outeiro, Tammaryn Lashley | |
13:00 | Prions, prion diseases and prion‐like disorders: evidence and implications Simon Mead, Professor of Neurology and Deputy Director, MRC Prion Unit at UCL, Institute of Prion Diseases, UCL, London | |
14:15 | Cell to cell propagation in primate models of PD and AD Jeff Kordower, The Alla V. and Solomon Jesmer Professor of Neurological Sciences, Department of Neurological Sciences, Rush Medical College, Chicago, USA | |
15:00 | Tea Break | |
15:30 | Neuronal vulnerability to tauopathy Karen Duff, Professor of Pathology and Cell Biology, Columbia University, New York, USA, and Honorary Professor, UCL, UK Dementia Research Institute Associate Director | |
16:15 | Molecular basis of disease heterogeneity in TDP‐43 proteinopathies Magdalini Polymendou, Professor of Biomedicine, Dept. of Quantitative Biomedicine, University of Zurich, Switzerland | |
17:00 | Short Break | |
17:15 | Dorothy Russell Memorial Lecture Transmission of Misfolded Proteins in Neurodegenerative Disorders: A Common Mechanism of Disease Progression Virginia Lee, The John H. Ware 3rd Endowed Professor in Alzheimer's Research University of Pennsylvania Perelman School of Medicine Director, Center for Neurodegenerative Disease Research | |
18.15 | Drinks Reception, UCL GOS ICH | |
Thursday 5th March 2020 | ||
08:00 | Registration | |
08:50 | Opening of meeting – Professor Colin Smith, BNS President | |
09:00–10:15 | FIRST SCIENTIFIC SESSION – Cerebrovascular disease | |
Chairs: Stephen Wharton, Roy Weller | ||
9:00 | R. Waller, P.R. Heath, J.E. Simpson, Y. Hase, R.N. Kalaria, S.B. Wharton What happens to cells of the brain in people who develop dementia after stroke? | O01 |
9:15 | Y Hase, V Foster, R Waller, JE Simpson, P Heath, SB Wharton, RN Kalaria Neocortical Non‐pyramidal Interneurons in Post‐stroke Survivors | O02 |
9:30 | S Saito, M Tanaka, N Satoh‐Asahara, R O Carare, R O Weller, M Ihara Taxifolin is a novel therapeutic agent for cerebral amyloid angiopathy | O03 |
9:45 | KE McAleese, M Mohi, S. Graham, G Baker, L Walker, C. DeCarli, D Koss, J. Attems The aetiology of frontal white matter lesions in Alzheimer's disease are associated with both neurodegenerative and ischemic mechanisms | O04 |
10:00 | J. Greenwood, T Wand, M Gatherer, A Keable, Z Rickard, C Smith, J.Attems, RO Weller, RO Carare Lymphatic marker LYVE1 is present in human brain parenchyma. | O05 |
10:15–10:45 | Coffee break and POSTER DISCUSSION | |
10:45–11:30 | Clinical update session: Practical diagnosis of embryonal tumours Professor Thomas Jacques | |
11:30–12:45 | SECOND SCIENTIFIC SESSION – CNS neoplasia | |
Chairs: Kathreena Kurian, Thomas Jacques | ||
11:30 | A. Tofias, H Barber, B Lander, A Daniels, JJ Gong, Y Ren, X Ren, Y Liang, P White, KM Kurian Advanced molecular characterization using Digital Spatial Profiling Technology on immuno‐oncology targets in methylated compared with unmethylated IDH‐wildtype glioblastoma | O06 |
11:45 | T. Millner, B. Ricci, X. Zhang, N. Pomella, S. Marino Pre‐clinical therapeutic targeting of a novel BMI1/Ephrin connection in human Glioblastomas | O07 |
12:00 | D. Ghasemi, K Okonechnikov, JP Mallm, K Lappalainen, K Bauer, MS Liberio, L Giese, KK Maass, M Kool, DTW Jones, A von Deimling, SM Pfister, A Korshunov, KW Pajtler Single Nucleus RNA‐sequencing reveals intratumoral heterogeneity in Medulloblastoma with Extensive Nodularity (MBEN) | O08 |
12:15 | E Byrne, D Pehl and M Hofer BCAT‐1 as a surrogate marker for IDH‐wildtype glioblastomas | O09 |
12:30 | I Smolicz, JC Pickles, TJ Stone, AR Fairchild, SW Ahmed, J Chalker, C Dryden, J Gonzalez Zapata, B Herron, AR Joshi, T Mistry, OK Ogunbiyi, A Rolland, L Wilkhu, SA Yasin, A Merve, BN Harding, D Hargrave, NJ Sebire, TS Jacques | |
Genetic alterations in advanced‐stage paediatric central nervous system tumours: a next‐generation sequencing study | O10 | |
12:45–14:00 | Lunch and POSTER DISCUSSION | |
14.00‐15.45 | THIRD SCIENTIFIC SESSION – Alpha‐synucleinopathies | |
Chair: Seth Love, Johannes Attems | ||
14:00 | S Patel, B Tilley, R K B Pearce, S Gentleman A Clinicopathological Investigation of Brainstem Nuclei in Dementia with Lewy Bodies and Parkinson's Disease Dementia | O11 |
14:15 | C. Bettencourt, SC Foti, Y Miki, IS Piras, J Botia, T Warner, T Revesz, T Lashley, R Balazs, E Viré, MJ Huentelman, JL Holton DNA methylome analysis in post‐mortem brain tissue of multiple system atrophy patients led to the identification of molecular changes in MOBP and other loci | O12 |
14:30 | T Eid, T Lashley, T Warner, R Bandopadhyay, J Hardy, J Holton and P Francis Altered Synaptic and Astrocytic Proteins in Alpha‐Synucleinopathies Associated with GBA Mutation | O13 |
14:45 | D. Koss D Erskine, J Attems, and T Outeiro Resolving the issue of nuclear localisation of alpha‐synuclein in Lewy body diseases | O14 |
15:00 | D. Erskine, K Sidhpura, HN Lai, DM Turnbull, J Attems Fast‐spiking interneuron vulnerability in dementia with Lewy bodies | O15 |
15:15 | D. Erskine, N Majbour, M Kauser, M Xylaki, J Attems, T Outeiro, O El‐Agnaf Regionally different expression of a novel α‐synuclein species between Parkinson's disease dementia and dementia with Lewy bodies | O16 |
15:30 | Y. Miki, H Ling, SC Foti, D Hansen, KM Strand, YT Asi, Z Jaunmuktane, AJ Lees, TT Warner, N Quinn, JL Holton Hippocampal α‐synuclein pathology correlates with memory impairment in multiple system atrophy | O17 |
15:45–16:15 | Coffee Break and POSTER DISCUSSION | |
16:15 | Neuropathology workload presentation. T. Dawson | |
16:30 | Business Meeting | |
17:30 | Professional Affairs Meeting | |
19:30 | Society Dinner At The Crypt | |
Friday 6th March 2020 | ||
08:00 | Registration | |
9:00–10:15 | FOURTH SCIENTIFIC SESSION – tau and Aβ proteinopathies | |
Chairs: Steve Gentleman, Colin Smith | ||
9:00 | K. McAleese, S Colloby, J Attems, A Thomas, PT Francis Mixed brain pathologies account for most dementia in the Brains for Dementia Research Cohort | O18 |
9:15 | S. Yap, MC Wren, B Frias Garrido, NC Fox, E Årstad, T Lashley, K Sander High sensitivity of tau radiotracers to depict tau spread in prodromal cases of Alzheimer's Disease | O19 |
9:30 | M. Matuszyk, L Ferraiuolo, A Taylor, P Davis, R Staniforth, CJ Garwood, SB Wharton Characterising the varying astrocyte response to oligomeric and fibrillar Aβ | O20 |
9:45 | S. Kaalund, L Passamonti, KSJ Allinson, AG Murley, TW Robbins, MG Spillantini, JB Rowe Locus coeruleus pathology in progressive supranuclear palsy is associated with disease severity. | O21 |
10:00 | L. Walker,E Jacobs, McAleese KE, Johnson M, and Attems J Do senescent cells play a role in Alzheimer's disease? | O22 |
10:15–10:45 | Coffee break and POSTER DISCUSSION | |
11:00–12:30 | FIFTH SCIENTIFIC SESSION – mixed neurodegenerative disorders | |
Chairs: Robin Highley, Tammaryn Lashley | ||
11:00 | P. Gami‐Patel, M. Scarioni, F. Bouwman, Y.A.L. Pijnenburg, P. Scheltens, A.J.M. Rozemuller, J.J.M. Hoozemans, A.A. Dijkstra Selective Vulnerability Of The Gabrq‐Expressing Population In The Anterior Cingulate Cortex in Frontotemporal Dementia | O23 |
11:15 | A. Oliver‐Evans, D Koss, A Thomas, D Erskine, J Attems Alterations to monoaminergic innervation in the medial prefrontal cortex in neurodegenerative diseases | O24 |
11:30 | B. Ashford, C.Appleby‐Mallinder, D. Boche, W. Wei, P. Heath, J.E Simpson, J.R Highey Exploring the Neuroinflammatory Response of the Motor Cortex and Spinal Cord in Human Motor Neurone Disease. | O25 |
11:45 | J. Mikol, J Delmotte, D Jouy, E Vaysset, JP Deslys, E Comoy Transmission of BSE in macaque after finger incision | O26 |
12:00 | R. Hickman, YJ Yang, KR Croce, CJ Griffey, K Kirwan, X Flowers, S Leskinen, K Marder, JPG Vonsattel, A Yamamoto Variation of Huntingtin aggregate density across the human neocortex of Huntington's disease may be partly due to neocortical differences in autophagic clearance | O27 |
12:15 | D. Koss, O Bondarevaite, S Adams, M Leite, J Attems, F Giorgini and T Outeiro Determination of the pathological involvement of the vesicular trafficking protein RAB39B in idiopathic variants of neurodegenerative disease | O28 |
12:30–13:45 | Lunch and POSTER DISCUSSION | |
13:45–14:30 | DIAGNOSTIC SLIDE SESSION (INCORPORATING EQA) | |
14:30–14:45 | Coffee break | |
14:45 | SIXTH SCIENTIFIC SESSION‐ Multiple sclerosis, epilepsy and mitochondrial disease | |
Chairs: Maria Thom, Colin Smith | ||
14:45 | B. Cooze, M. Dickerson, R. Loganathan, R. Magliozzi, R. Bevan, L. Watkins, R. Reynolds, JW. Neal, OW. Howell The contribution of thalamic pathology to progressive multiple sclerosis outcome | O29 |
15:00 | M. Pisa, S. Yee, A. Smart, E. Simoes, M.M. Esiri, L. Leocani, G.C.DeLuca Anterior optic pathway pathology in demyelinating CNS diseases | O30 |
15:15 | C. Chen, D. McDonald, A. Blain, A. Sachdeva, L. Boyd, A. Smith, C. Warren, C. Lawless, A. Filby, A. Vincent, D. Turnbull, A. Reeve Imaging mass cytometry analysis of mitochondrial defect in human substantia neuron: Complex I deficiency and beyond | O31 |
15:30 | L. Smith, D Erskine, N Lax, R Taylor, R McFarland The specific loss of interneurons underlying epilepsy in Alpers‐Huttenlocher Syndrome | O32 |
15:45 | E. Olkhova, C Bradshaw, YS Ng, NZ Lax, FEN LeBeau, GS Gorman Investigating hyperexcitable neuronal networks in mitochondrial disease | O33 |
16:00–16.30 | Close of Conference and Abstract Award Presentations |
Poster Presentations | |
Displayed in the Philip Ullman Wing of UCL GOS ICH 5th – 6th March 2020 | |
M. Jensen, KSJ Allinson Clinico‐Pathological Co‐Occurrence of Fahr's Disease and Dementia with Lewy Bodies | P01 |
N. Malik, M. Miah, K. McAleese, T. Outeiro, A. Thomas and D. Koss Contribution of amyloid and tau white matter pathology to the spatial spread of Alzheimer's disease pathology | P02 |
I.Hartnell, D Blum, J A R Nicoll, G Dorothee, D Boche The role of neuroinflammation in FTLD‐tau | P03 |
R. Beardmore, D. Boche, A. Darekar, M. Durkin, C. Holmes, R. Hou The locus coeruleus in Alzheimer's disease: a potential biomarker | P04 |
N. Visanji, A Maluach, AE Lang, GG Kovacs A systematic neuropathologic evaluation of Down syndrome: a complex multiproteinopathy | P05 |
A. King, C Troakes, I Bodi, C McLoughlin, H‐J Chen, C E Shaw Neuropathological features of ALS cases with TARDBP mutations both adjacent to, and distant from, RNA binding domains | P06 |
C. Bettencourt, SC Foti, Y Miki, T Warner, T Revesz, T Lashley, R Balazs, E Viré, JL Holton Parallel profiling of DNA methylation and hydroxymethylation in post‐mortem brain tissue of multiple system atrophy patients | P07 |
M. Ali, J Nimmo, M MacGregor‐Sharp, D.A. Johnston, R.O. Weller, R.O.Carare Advances in 3D‐imaging of tracers in the brain. Significance for Alzheimer's disease. | P08 |
K. McAleese, L Walker, D Erskine, J Attems The impact of concomitant LATE‐NC on hyperphosphorylated‐τ pathology and cognitive decline in Alzheimer's disease | P09 |
K. Ebanks, J. Hardy, T. Warner, P. Lewis, R. Bandopadhyay Analysis of selective vesicular proteins in Parkinson's disease pathogenesis | P10 |
E. Placido, D J Koss, P S Brocardo, T F Outeiro Cell proliferation and differentiation in Parkinson`s Disease | P11 |
P. Greer, A Reeve, I McKeith, D Erskine Astrocytic α‐synucleinopathy in dementia with Lewy bodies | P12 |
C. Hatton, YS Ng, DM Turnbull, D Erskine The cholinergic basal forebrain and cognitive impairment in mitochondrial disease and Lewy body dementia | P13 |
B. Boon, M Bulk, AJ Jonker, THJ Morrema, E van den Berg, M Popovic, J Walter, S Kumar, R Natté, L van der Weerd, FH Bouwman, WDJ van de Berg, JJM Hoozemans, AJM Rozemuller The coarse‐grained Aβ plaque; a ‘new’ kid on the block in early‐onset Alzheimer's disease, showing a strong association with both inflammatory and vascular changes | P14 |
S Jones, C Troakes, I Bodi Tau‐positive glial cytoplasmic granules are hallmark of multiple system atrophy | P15 |
Z. Reisz, I Bodi Fatal thrombolysis‐related intracerebral haemorrhagic complication associated with amyloid‐β‐related angiitis | P16 |
B. Frias, A Isaacs,T Lashley Characterisation of SRSF2 in neurodegenerative diseases | P17 |
H. Rupawala, K Shah, X Peng, L Granat, J Rose, C Troakes, A Morgan, T Hortobagyi, T Spires‐Jones, W Noble, KP Giese Plaque Associated CSPalpha Protein Accumulations Discovered in Alzheimer's Disease | P18 |
C. Troakes, A. Hye, S. Jones, R. Killick, S. Al‐Sarraj DKK‐1 is associated with pathological hallmarks in Alzheimer's disease and other tauopathies and is also seen in head injury | P19 |
E. Velentza‐Almpani, N. Bengoa‐Vergniory, A. Silva, C. Scott, J. Spence, M. Sastre, R. Wade‐Martins, J. Alegre‐Abarrategui Understanding the pathophysiological role of early tau aggregates in Alzheimer's disease by their direct visualisation in situ | P20 |
E. Comoy, J Mikol, J Delmotte, E Vaysset, D Jouy, JP Deslys Risk analysis of low‐dose prion exposures in cynomolgus macaque | P21 |
C. Pang, MH Soerensen, K Lee, KC Luk, VMY Lee, JQ Trojanowski, W Noble, RCC Chang Using 6OHDA and aSyn PFFs to explore the role of tau mediated loss of synaptic dysfunction leading to cognitive dysfunction in Parkinson's disease | P22 |
S. Yee, R. L. Yates, M. M. Esiri, G. C. DeLuca Perivascular Astrocyte Expression in the Multiple Sclerosis Motor Cortex | P23 |
A.Dijkstra, S.Haify, N.A. Verwey, N.D. Prins, L.W. Severijnen, A.J.M. Rozemuller, W.F.A. den Dunnen, R.Willemsen, R.K. Hukema, J.J.M. Hoozemans Neuropathology of Fragile‐X associated neuropsychiatric disorders (FXAND) | P24 |
S. Patodia, A. Somani, A. Cattaneo, B. Paradiso, M. Garcia, B. Diehl, J. Foong, M. Thom Serotonin Transporter in Temporal Lobe and Amygdala: Relationship to Psychiatric History and SUDEP | P25 |
S. Patodia, F. Chung, A. Somani, M. Thom Increased c‐fos neurones in the anterior cingulate cortex in SUDEP | P26 |
L. Wilson, L. Heraty, B. Ashford, J. Highley Tissue Microarray (TMA) Use in Post Mortem Neuropathology | P27 |
O. Jennings, A Ajikumar, PR Heath, SB Wharton, JE Simpson Transcriptomic profile of the blood‐brain barrier in age‐associated white matter lesions | P28 |
E. Georgiou, I Coldicott, A Varcianna, P R Heath Use of FACs to isolate targeted neurons for transcriptomic analysis | P29 |
A.Kumar, G Soosay, M Thom Amoebic encephalitis mimicking CNS tumour : A case report | P30 |
Z. Reisz, M Gallagher, K Ashkan, C Fisher, I Bodi Intraventricular myxoid angiomatoid fibrous histiocytoma with EWSR1 rearrangement | P31 |
E. Byrne, C Turnquist, D Pehl, M Hofer Meningothelial hamartoma: two case illustrations and a literature review | P32 |
E. Byrne C Turnquist, D Pehl, M Hofer A rare dural ‐based lesion: Histology and a literature review | P33 |
V. Mikkelsen, HY Dai, AL Stensjøen, EM Berntsen, Ø Salvesen, O Solheim, SH Torp MGMT promoter methylation status is not related to histological or radiological features in treatment‐naïve glioblastoma patients | P34 |
R. Solomon, A Ismail How specific do histology of diffuse glioma and 1p19q status correlate? | P35 |
C. Turnquist, E. Byrne, D. Pehl, M. Hofer, N. Gray, G. Turner A case study of primary central nervous system T‐cell lymphoma | P36 |
C. Turnquist, E. Byrne, D. Pehl, M. Hofer A case series of focal areas of signal intensity (FASI) in neurofibromatosis type 1 | P37 |
I. Wickersham, L. Rutigliani, T. Lavin, HA. Sullivan, M. Matsuyama Evaluating Monosynaptic Properties of Second‐Generation Rabies Virus Tracing Technique | P38 |
S Chakraborti, P Pal Audit of molecular data obtained on gliomas between January 2018 to May 2019 at The Walton Centre | P39 |
中文翻译:
英国神经病理学会UCL英国大奥蒙德街儿童健康研究所第121届会议,伦敦
研讨会2020年3月4日,星期三
神经退行性变:神经退行性疾病中错折叠蛋白的The病毒样特性
主持人:英国纽卡斯尔纽卡斯尔大学Tiago Outeiro教授和德国哥廷根哥廷根大学医学中心 | ||
Tammaryn Lashley博士,英国伦敦大学学院皇后广场神经病学研究所皇后广场脑库研究主管,神经退行性疾病首席研究员 | ||
12:00 | 注册 | |
12:50 | 欢迎和介绍 Tiago Outeiro,塔玛琳·拉什利 | |
13:00 | ions病毒,病毒疾病和类似ion病毒的疾病:证据和启示 西蒙·米德(Simon Mead),伦敦大学伦敦分校疾病研究所,伦敦大学伦敦分校神经病学教授兼MRC监狱部副主任 | |
14:15 | PD和AD灵长类动物模型中的细胞到细胞繁殖 Jeff Kordower,The Alla V.和Solomon Jesmer神经科学教授,拉什医学院,神经科学系,美国芝加哥 | |
15:00 | 下午茶 | |
15:30 | 牛磺酸对神经元的脆弱性 Karen Duff,美国纽约哥伦比亚大学病理学和细胞生物学教授,英国痴呆研究所UCL名誉教授,副主任 | |
16:15 | TDP-43蛋白病中疾病异质性的分子基础 Magdalini Polymendou,瑞士苏黎世大学定量生物医学系教授 | |
17:00 | 短暂休息 | |
17:15 | Dorothy Russell纪念讲座神经退行性疾病中错误折叠蛋白的传递:疾病发展的常见机制 弗吉尼亚·李,约翰·H·韦尔宾夕法尼亚大学阿尔兹海默氏病研究基金会第三任教授佩雷尔曼医学院神经退行性疾病研究中心主任 | |
18.15 | UCL GOS ICH酒会 | |
2020年3月5日,星期四 | ||
08:00 | 注册 | |
08:50 | 会议开幕– BNS总裁Colin Smith教授 | |
09:00–10:15 | 第一次科学会议–脑血管疾病 | |
主持人:斯蒂芬·沃顿,罗伊·韦勒 | ||
9:00 | R. Waller, PR Heath,JE Simpson,Y。Hase,RN Kalaria,SB Wharton中风后患痴呆症的人的脑细胞会发生什么变化? | O01 |
9:15 | Y Hase, V Foster,R Waller,JE Simpson,P Heath,SB Wharton,RN卒中后幸存者的新皮层非锥体神经元 | O02 |
9:30 | S Saito, M Tanaka,N Satoh-Asahara,RO Carare,RO Weller,M Ihara Taxifolin是一种新型的脑淀粉样血管病治疗剂 | O03 |
9:45 | KE McAleese, M Mohi,S.Graham,G Baker,L Walker,C.DeCarli,D Koss,J.Attems阿尔茨海默氏病中额叶白质病的病因与神经退行性和缺血性机制相关 | O04 |
10:00 | J. Greenwood, T Wand,M Gatherer,A Keable,Z Rickard,C Smith,J.Attems,RO Weller,RO Carare淋巴结标记LYVE1存在于人类脑实质中。 | O05 |
10:15–10:45 | 茶歇和海报讨论 | |
10:45–11:30 | 临床最新动态:胚胎肿瘤的实用诊断Thomas Jacques教授 | |
11:30–12:45 | 第二届学术会议–中枢神经系统肿瘤 | |
主持人:凯瑟琳娜·库里安(Kathreena Kurian),托马斯·雅克(Thomas Jacques) | ||
11:30 | A.Tofias, H Barber,B Lander,A Daniels,JJ Gong,Y Ren,X Ren,Y Liang,P White,KM Kurian使用数字空间分析技术对甲基化的免疫肿瘤靶标进行了先进的分子表征,而未甲基化的IDH-野生型胶质母细胞瘤 | O06 |
11:45 | T. Millner,B.Ricci,X.Zhang,N.Pomella,S.Marino对人胶质母细胞瘤中新型BMI1 / Ephrin连接的临床前治疗靶向 | O07 |
12:00 | D.Ghasemi, K Okonechnikov,JP Mallm,K Lappalainen,K Bauer,MS Liberio,L Giese,KK Maass,M Kool,DTW Jones,A von Deimling,SM Pfister,A Korshunov,KW Pajtler单核RNA测序揭示了瘤内广泛结节性髓母细胞瘤(MBEN)的异质性 | O08 |
12:15 | E Byrne, D Pehl和M Hofer BCAT-1作为IDH野生型胶质母细胞瘤的替代标志物 | O09 |
12:30 | 我Smolicz, JC Pickles,TJ Stone,AR Fairchild,SW Ahmed,J Chalker,C Dryden,J Gonzalez Zapata,B Herron,AR Joshi,T Mistry,OK Ogunbiyi,A Rolland,L Wilkhu,SA Yasin,A Merve,BN哈丁,D哈格拉夫,新泽西州塞比尔,TS雅克 | |
儿科中枢神经系统晚期肿瘤的遗传改变:下一代测序研究 | O10 | |
12:45–14:00 | 午餐和海报讨论 | |
14.00-15.45 | 第三届学术会议–α-突触核病 | |
主持人:塞思·洛夫(Seth Love),约翰内斯·阿特姆斯(Johannes Attems) | ||
14:00 | S Patel,B Tilley,RKB Pearce,S Gentleman A路易氏体和帕金森氏病痴呆患者痴呆脑干核的临床病理研究 | O11 |
14:15 | C.Bettencourt, SC Foti,Y Miki,IS Piras,J Botia,T Warner,T Revesz,T Lashley,R Balazs,EViré,MJ Huentelman,JL Holton在多系统萎缩患者的死后脑组织中进行DNA甲基化分析导致鉴定了MOBP和其他基因座的分子变化 | O12 |
14:30 | T Eid, T Lashley,T Warner,R Bandopadhyay,J Hardy,J Holton和P Francis改变了与GBA突变相关的α-突触核蛋白病中的突触和星形胶质蛋白。 | O13 |
14:45 | D. Koss D Erskine,J Attems和T Outeiro解决路易体病中α-突触核蛋白的核定位问题 | O14 |
15:00 | D.厄斯金, ķ西德普拉,HN赖,DM特恩布尔,J Attems快速扣球中间神经元漏洞路易体痴呆 | O15 |
15:15 | D. Erskine, N Majbour,M Kauser,M Xylaki,J Attems,T Outeiro,O El-Agnaf在帕金森氏病痴呆和路易体痴呆之间,新型α-突触核蛋白物种的区域表达不同 | O16 |
15:30 | Y. Miki, H Ling,SC Foti,D Hansen,KM Strand,YT Asi,Z Jaunmuktane,AJ Lees,TT Warner,N Quinn,JL Holton海马α-突触核蛋白病理与多系统萎缩中的记忆障碍相关 | O17 |
15:45–16:15 | 茶歇和海报讨论 | |
16:15 | 神经病理学工作量演示。道森 | |
16:30 | 商务会议 | |
17:30 | 专业事务会议 | |
19:30 | 土窖的社会晚宴 | |
2020年3月6日,星期五 | ||
08:00 | 注册 | |
9:00–10:15 | 第四届科学会议– tau和Aβ蛋白病 | |
主持人:史蒂夫·绅士,科林·史密斯 | ||
9:00 | K. McAleese, S Colloby,J Attems,A Thomas,PT弗朗西斯(Francis)混合性脑病是痴呆研究人群中大多数痴呆的原因 | O18 |
9:15 | S. Yap, MC Wren,B Frias Garrido,NC Fox,EÅrstad,T Lashley,K Sander对tau放射性示踪剂的高敏感性可以描述tau在阿尔茨海默氏病前驱病例中的扩散 | O19 |
9:30 | M. Matuszyk, L Ferraiuolo, A Taylor,P Davis,R Staniforth,CJ Garwood,SB Wharton表征星形胶质细胞对寡聚和原纤维Aβ的不同反应 | O20 |
9:45 | S. Kaalund, L Passamonti,KSJ Allinson,AG Murley,TW Robbins,MG Spillantini,JB Rowe Locus蓝斑病在进展性核上性麻痹中的病理与疾病严重程度相关。 | O21 |
10:00 | L. Walker, E Jacobs,McAleese KE,Johnson M和Attems J衰老细胞是否在阿尔茨海默氏病中起作用? | O22 |
10:15–10:45 | 茶歇和海报讨论 | |
11:00–12:30 | 第五届科学会议–混合性神经退行性疾病 | |
主持人:罗宾·海利(Robin Highley),塔玛琳·拉什利(Tammaryn Lashley) | ||
11:00 | P. GAMI-帕特尔, M. Scarioni,F. Bouwman,YAL Pijnenburg,P. Scheltens,AJM Rozemuller,JJM Hoozemans,AA的Dijkstra在额颞痴呆选择性脆弱性的Gabrq表达人口前扣带皮层 | O23 |
11:15 | A. Oliver-Evans, D Koss,A Thomas,D Erskine,J Attems神经退行性疾病中前额叶皮层单胺能神经支配的改变 | O24 |
11:30 | B.阿什福德, C.Appleby-Mallinder,D.博凯,W.伟P.希思,JE辛普森,JR Highey探索人类运动神经元疾病的运动皮质和脊髓的神经炎症反应。 | O25 |
11:45 | J. Mikol, J Delmotte,D Jouy,E Vaysset,JP Deslys,E Comoy在手指切口后在猕猴中传播BSE | O26 |
12:00 | R. Hickman, YY Yang,KR Croce,CJ Griffey,K Kirwan,X Flowers,S Leskinen,K Marder,JPG Vonsattel,山本人在亨廷顿氏病人类新皮层中的亨廷顿聚集密度变化可能部分归因于新皮层差异自噬清除 | O27 |
12:15 | D. Koss,O Bondarevaite,S Adams,M Leite,J Attems,F Giorgini和T Outeiro确定水泡运输蛋白RAB39B在神经退行性疾病特发性变体中的病理学参与 | O28 |
12:30–13:45 | 午餐和海报讨论 | |
13:45–14:30 | 诊断幻灯片会议(包含EQA) | |
14:30–14:45 | 咖啡时间(休闲时光 | |
14:45 | 第六届科学会议-多发性硬化症,癫痫和线粒体疾病 | |
主持人:玛丽亚·汤姆(Maria Thom),科林·史密斯(Colin Smith) | ||
14:45 | B.Cooze,M.Dickerson,R.Loganathan,R.Magliozzi,R.Bevan,L.Watkins, R.Reynolds,JW。尼尔,OW。豪威尔丘脑病理学对进行性多发性硬化症结局的贡献 | O29 |
15:00 | M. Pisa, S。Yee,A。Smart,E。Simoes,MM Esiri,L.Leocani,GCDeLuca脱髓鞘性中枢神经系统疾病的前路光学通路病理 | O30 |
15:15 | C. Chen, D.McDonald,A.Blain,A.Sachdeva,L.Boyd,A.Smith,C.Warren,C.Lawless,A.Filby,A.Vincent,D.Turnbull,A.Reeve Imaging mass cytometry实质神经元线粒体缺陷的分析:复合体I缺乏症及其他 | O31 |
15:30 | L.史密斯, d厄斯,N松懈,R泰勒,R麦克法兰在阿尔珀斯-Huttenlocher综合征底层癫痫的interneurons的具体损失 | O32 |
15:45 | E. Olkhova, C Bradshaw,YS Ng,NZ Lax,FEN LeBeau,GS Gorman研究线粒体疾病中的过度兴奋性神经元网络 | O33 |
16:00–16.30 | 会议闭幕和摘要颁奖典礼 |
海报展示 | |
于UCL GOS ICH的Philip Ullman翼中展出2020年3月5日至6日 | |
M. Jensen和KSJ Allinson Fahr病和痴呆与路易体的临床病理并发 | P01 |
N. Malik, M。Miah,K。McAleese,T。Outeiro,A。Thomas和D. Koss淀粉样蛋白和tau白质病理对阿尔茨海默氏病病理空间分布的贡献 | P02 |
I.Hartnell, D Blum,JAR Nicoll,G Dorothee, DBoche神经炎症在FTLD-tau中的作用 | P03 |
R. Beardmore, D.Boche,A.Darekar,M.Durkin,C.Holmes,R.Hou阿尔茨海默氏病中的蓝斑基因:潜在的生物标记 | P04 |
N. Visanji, A Maluach,AE Lang,GG Kovacs对唐氏综合症的系统神经病理学评估:一种复杂的多蛋白病 | P05 |
A. King, C Troakes,I Bodi,C McLoughlin,HJ Chen,CE Shaw TALSBP突变且与RNA结合域相邻且相距较远的ALS病例的神经病理学特征 | P06 |
C. Bettencourt, SC Foti,Y Miki,T Warner,T Revesz,T Lashley,R Balazs,EViré,JL Holton进行多系统萎缩患者死后脑组织DNA甲基化和羟甲基化的平行分析 | P07 |
M. Ali, J Nimmo,M MacGregor-Sharp,DA Johnston,RO Weller,ROCarare大脑中示踪剂的3D成像技术不断进步。对阿尔茨海默氏病的意义。 | P08 |
K. McAleese, L Walker,D Erskine,J Attems伴随的LATE-NC对阿尔茨海默氏病的高磷酸化-τ病理和认知功能下降的影响 | P09 |
K. Ebanks, J。Hardy,T。Warner,P。Lewis,R。Bandopadhyay分析帕金森病发病机理中的选择性囊泡蛋白 | P10 |
E. Placido, DJ Koss,PS Brocardo,TF Outeiro帕金森氏病中的细胞增殖和分化 | P11 |
P. Greer, A Reeve,I McKeith,D Erskine星形胶质细胞性痴呆伴路易小体 | P12 |
C. Hatton, YS Ng,DM Turnbull,D Erskine线粒体疾病和路易体痴呆症的胆碱能基础前脑和认知障碍 | P13 |
B.文中,M批量,AJ的Jonker,THJ Morrema,E范登贝尔赫,男Popovic的,J沃尔特,S库马尔,RNatté,L范德瓦Weerd,FH Bouwman,WDJ范·德·伯格,JJM Hoozemans,AJM Rozemuller粗粒状Aβ斑块;一个早发的阿尔茨海默氏病的“新”孩子,与炎症和血管变化密切相关 | P14 |
S Jones,C Troakes,I Bodi Tau阳性胶质细胞质颗粒是多系统萎缩的标志 | P15 |
Z. Reisz, I Bodi 与淀粉样β相关的血管炎相关的致命溶栓相关性脑出血并发症 | P16 |
B. Frias, Isaacs,T Lashley神经退行性疾病中SRSF2的表征 | P17 |
H. Rupawala, K Shah,X Peng,L Granat,J Rose,C Troakes,A Morgan,T Hortobagyi,T Spires‐Jones,W Noble,KP在阿兹海默氏病中发现的Giese斑块相关的CSPalpha蛋白积累 | P18 |
C. Troakes,A。Hye,S。Jones,R。Killick,S。Al -Sarraj DKK-1与阿尔茨海默氏病和其他tauopathies的病理标志有关,也可见于头部受伤 | P19 |
E. Velentza-Almpani, N.Bengoa -Vergniory, A.Silva, C.Scott, J.Spence, M.Sastre, R.Wade-Martins,J.Alegre-Abarrategui了解早期tau聚集体在阿尔茨海默氏病中的病理生理作用通过直接观察原位 | P20 |
E. Comoy, J Mikol,J Delmotte,E Vaysset,D Jouy,JP Deslys食蟹猕猴低剂量病毒暴露的风险分析 | P21 |
C. Pang, MH Soerensen,K Lee,KC Luk,VMY Lee,JQ Trojanowski,W Noble,RCC Chang使用6OHDA和aSyn PFF探索tau介导的突触功能障碍丧失导致帕金森氏病的认知功能障碍的作用 | P22 |
S. Yee, RL Yates,MM Esiri,GC DeLuca多发性硬化运动皮层中血管星形胶质细胞的表达 | P23 |
A.Dijkstra, S.Haify,NA Verwey,ND Prins,LW Severijnen,AJM Rozemuller,WFA den Dunnen,R.Willemsen,RK Hukema,JJM Hoozemans脆弱X相关神经精神疾病(FXAND)的神经病理学 | P24 |
S. Patodia, A。Somani, A。Cattaneo, B.Paradiso, M。Garcia, B.Diehl, J.Foong, M。Thom颞叶和杏仁核中的血清素转运蛋白:与精神病史和SUDEP的关系 | P25 |
S. Patodia, F。Chung, A。Somani, M。Thom在SUDEP的前扣带回皮质中增加c-fos神经元 | P26 |
L. Wilson, L.Heraty,B.Ashford,J.Highley组织微阵列(TMA)在后态神经病理学中的应用 | P27 |
O. Jennings, A Ajikumar,PR Heath,SB Wharton,JE Simpson与年龄相关的白质病变中血脑屏障的转录组学特征 | P28 |
E. Georgiou, I Coldicott,A Varcianna,PR Heath使用FAC分离目标神经元以进行转录组分析 | P29 |
A.Kumar,G Soosay,M Thom模仿CNS肿瘤的阿米巴性脑炎:一例报告 | P30 |
Z. Reisz, M Gallagher,K Ashkan,C Fisher,I Bodi EWSR1重排的脑室内粘液样血管瘤样纤维组织细胞瘤 | P31 |
E. Byrne, C Turnquist,D Pehl,M Hofer脑膜错构瘤:两个病例插图和文献复习 | P32 |
E. Byrne C Turnquist,D Pehl,M Hofer一种罕见的基于硬脑膜的病变:组织学和文献综述 | P33 |
V. Mikkelsen, HY Dai,ALStensjøen,EM Berntsen,ØSalvesen,O Solheim,SH Torp MGMT启动子甲基化状态与未接受过治疗的胶质母细胞瘤患者的组织学或放射学特征无关 | P34 |
R. Solomon,A Ismail弥漫性神经胶质瘤的组织学与1p19q状态之间有何具体联系? | P35 |
C. Turnquist, E.拜恩,D. Pehl,M. Hofer的,N.灰色,G.特纳原发性中枢神经系统T细胞淋巴瘤为例 | P36 |
C. Turnquist, E.拜恩,D. Pehl,M. Hofer的在型神经纤维瘤病1的情况下一系列的信号强度(FASI)的病灶区的 | P37 |
I. Wickersham,L。Rutigliani,T。Lavin,HA。Sullivan,M。Matsuyama评估第二代狂犬病病毒追踪技术的单突触特性 | P38 |
S Chakraborti, P Pal 2018年1月至2019年5月间在沃尔顿中心对神经胶质瘤分子数据的审核 | P39 |