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Self-Adhesive Microneedles with Interlocking Features for Sustained Ocular Drug Delivery.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-04-27 , DOI: 10.1002/mabi.202000089
Maher Amer 1 , Roland K Chen 1
Affiliation  

The interests in sustained ocular drug delivery have grown rapidly in recent years, with hope to replace repeated intravitreal injections. Microneedles (MNs), which are minimally invasive, have been shown to be a feasible vehicle for sustained drug delivery. However, securing an MN patch in the eye remains challenging. In this study, a new design of hydrogel MNs with interlocking features to achieve self‐adhesion is proposed. Upon swelling, the swollen interlocking features help secure the MNs in place. A new molding process is developed to fabricate MNs with interlocking features that can cause issues when demolding using the regular micromolding process. MNs with two different interlocking feature designs are used in this study and are made with polyvinyl alcohol. MNs with the interlocking features show an 80% increase in adhesion strength and a small amount of increase in penetration force, in comparison to MNs without any feature. The experiments are performed using both a sclera‐mimicking phantom and ex vivo eyes harvested from rabbits and are shown to have comparable results. This study demonstrates the feasibility of incorporating interlocking features to MNs to achieve self‐adhesion that can enable sustained drug delivery via MNs.

中文翻译:

具有互锁功能的自粘微针,可实现持续的眼部药物输送。

近年来,对于持续的眼部药物递送的兴趣迅速增长,希望能够代替重复的玻璃体内注射。微针(MNs)具有微创性,已被证明是持续药物输送的可行载体。然而,将MN贴片固定在眼睛中仍然是挑战。在这项研究中,提出了一种具有互锁功能的水凝胶微胶囊新设计,以实现自粘。膨胀时,膨胀的互锁功能有助于将MN固定到位。开发了一种新的成型工艺来制造具有互锁特征的MN,当使用常规的微成型工艺进行脱模时,这些互锁特性会引起问题。在这项研究中使用了具有两种互锁特征设计的MN,它们是由聚乙烯醇制成的。与没有任何特征的MN相比,具有互锁特征的MNs的粘合强度提高了80%,而穿透力却有少量增加。实验是使用模仿巩膜的体模和从兔子身上获得的离体眼睛进行的,并显示出可比的结果。这项研究证明了将互锁特征结合到MN上以实现自粘的可行性,这种粘附可以实现通过MN的持续药物输送。
更新日期:2020-04-27
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