OBJECTIVE The purpose of this work was to explore the enhancement effect of zinc doped mesoporous silica nanoparticles (Zn-MSNs), which could form micromechanical interlocking with resin matrix and sustainably release Zn2+, on the mechanical and antibacterial properties of the dental resin composites. METHODS Zn-MSNs were prepared by a sol-gel method, and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and N2 adsorption/desorption. The mechanical properties of the dental composites reinforced by Zn-MSNs were measured by a universal mechanical testing machine. Antibacterial activities of dental composites were evaluated by both qualitative and quantitative analysis using Streptococcus mutans (S. mutans). The cytotoxicity of the Zn-MSNs filled dental composites was investigated by osteoblasts (OBs). RESULTS The synthesized Zn-MSNs possessed good monodispersity with an average particle size of about 138nm. The mechanical properties of the composites gradually increased with the increase of the content of Zn-MSNs. The flexural strength, flexural modulus, compressive strength and micro-hardness of the composites containing 15wt% Zn-MSNs were 31.21%, 50.47%, 53.83% and 26.79% higher than the samples with no Zn-MSNs, respectively. The antibacterial performance was significantly improved by the addition of Zn-MSNs and the antibacterial rate of the composite with 15wt% of Zn-MSNs reached 100%. Cytotoxicity tests revealed that all the composites were biocompatible during OBs incubation. SIGNIFICANCE The prepared Zn-MSNs can effectively improve the mechanical and antibacterial properties of the dental resin composites.

中文翻译：

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制备锌掺杂的介孔二氧化硅纳米粒子（Zn-MSNs），用于改善牙科树脂复合材料的机械和抗菌性能。

目的这项工作的目的是探讨锌掺杂的介孔二氧化硅纳米颗粒（Zn-MSNs）对牙科树脂复合材料的机械和抗菌性能的增强作用，该纳米颗粒可以与树脂基体形成微机械互锁并可持续释放Zn2 +。方法采用溶胶-凝胶法制备Zn-MSNs，并通过扫描电子显微镜（SEM），透射电子显微镜（TEM）和N 2吸附/脱附进行表征。Zn-MSNs增强的牙科复合材料的力学性能是通过通用机械测试仪测量的。使用变形链球菌（变形链球菌）通过定性和定量分析评估了牙科复合材料的抗菌活性。Zn-MSNs填充牙科复合材料的细胞毒性通过成骨细胞（OBs）进行了研究。结果合成的Zn-MSN具有良好的单分散性，平均粒径约为138nm。随着Zn-MSNs含量的增加，复合材料的力学性能逐渐提高。含有15wt％Zn-MSNs的复合材料的弯曲强度，弯曲模量，抗压强度和显微硬度分别比不含Zn-MSNs的样品高31.21％，50.47％，53.83％和26.79％。Zn-MSNs的加入显着提高了抗菌性能，Zn-MSNs的含量为15wt％时复合材料的抗菌率达到100％。细胞毒性测试表明，在OB孵育过程中，所有复合材料均具有生物相容性。意义制备的Zn-MSNs可有效改善牙科树脂复合材料的机械和抗菌性能。