当前位置: X-MOL 学术Cell Calcium › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Multiple facets of TRPML1 in autophagy.
Cell Calcium ( IF 4.3 ) Pub Date : 2020-04-27 , DOI: 10.1016/j.ceca.2020.102196
Peng Huang 1 , Mengnan Xu 2 , Yi Wu 1 , Alia Kazim Rizvi Syeda 2 , Xian-Ping Dong 2
Affiliation  

Autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. In a recent study, Scotto-Rosato et al. demonstrate that TRPML1-mediated calcium release promotes autophagosome biogenesis by activating the CaMKKβ/VPS34 pathway, providing a new insight into the pathophysiological role of TRPML1 in human diseases.

中文翻译:


TRPML1 在自噬中的多个方面。



自噬是一种进化上保守的途径,是细胞稳态、生长和生存所必需的。在最近的一项研究中,Scotto-Rosato 等人。证明 TRPML1 介导的钙释放通过激活 CaMKKβ/VPS34 途径促进自噬体生物发生,为 TRPML1 在人类疾病中的病理生理学作用提供了新的见解。
更新日期:2020-04-27
down
wechat
bug