Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? A Case-Control Study with Service and Research Implications for Immunopsychiatry,Brain, Behavior, and Immunity

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Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? A Case-Control Study with Service and Research Implications for Immunopsychiatry
Brain, Behavior, and Immunity ( IF 8.8 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.bbi.2020.04.069
Fengyi Hao ₁ , Wanqiu Tan ₂ , Li Jiang ₁ , Ling Zhang ₁ , Xinling Zhao ₁ , Yiran Zou ₁ , Yirong Hu ₁ , Xi Luo ₁ , Xiaojiang Jiang ₃ , Roger S McIntyre ₄ , Bach Tran ₅ , Jiaqian Sun ₆ , Zhisong Zhang ₇ , Roger Ho ₈ , Cyrus Ho ₉ , Wilson Tam ₁₀

Affiliation

The First People's Hospital of Chongqing Liang Jiang New Area, Chongqing, China.
Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 119077, Singapore; The China-Singapore (Chongqing) Demonstration Initiative on Strategic Connectivity Think Tank, Chongqing 400043, China.
Department of Neurology, Daping Hospital, Army Medical University, Chongqing, China.
Mood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Canada.
Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, United States; Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, Viet Nam.
Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.
Faculty of Education, Huaibei Normal University, Huaibei 235000, China.
Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 119077, Singapore; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore.
Department of Psychological Medicine, National University Health System, Singapore.
Alice Lee Centre for Nursing Studies, National University of Singapore, Singapore.

Abstract This study aimed to assess and compare the immediate stress and psychological impact experienced by people with and without psychiatric illnesses during the peak of 2019 coronavirus disease (COVID-19) epidemic with strict lockdown measures. Seventy-six psychiatric patients and 109 healthy control subjects were recruited from Chongqing, China and completed a survey on demographic data, physical symptoms during the past 14 days and a range of psychiatric symptoms using the Impact of Event Scale- Revised (IES-R), Depression, Anxiety and Stress Scale (DASS-21) and Insomnia Severity Index (ISI). IES-R measures PTSD symptoms in survivorship after an event. DASS -21 is based on tripartite model of psychopathology that comprise a general distress construct with distinct characteristics. The mean IES-R, DASS-21 anxiety, depression and stress subscale and ISI scores were higher in psychiatric patients than healthy controls (p<0.001). Serious worries about their physical health, anger and impulsivity and intense suicidal ideation were significantly higher in psychiatric patients than healthy controls (p<0.05). More than one-third of psychiatric patients might fulfil the diagnostic criteria post-traumatic stress disorder (PTSD). More than one-quarter of psychiatric patients suffered from moderately severe to severe insomnia. Respondents who reported no change, poor or worse physical health status and had a psychiatric illness were significantly more likely to have higher mean IES-R, DASS depression, anxiety and stress subscale scores and ISI scores (p<0.05). This study confirms the severity of negative psychological impact on psychiatric patients during the COVID-19 epidemic with strict lockdown measures. Understanding the psychological impact on psychiatric patients during the COVID-19 pandemic has the potential to provide insight into how to develop a new immunopsychiatry service. Further research is required to compare pro-inflammatory cytokines between psychiatric patients and healthy controls during the pandemic.

更新日期：2020-07-01

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