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Bioprintable tough hydrogels for tissue engineering applications.
Advances in Colloid and Interface Science ( IF 15.9 ) Pub Date : 2020-04-25 , DOI: 10.1016/j.cis.2020.102163
Pramod Dorishetty 1 , Naba K Dutta 1 , Namita Roy Choudhury 1
Affiliation  

Bioprinting is an advanced fabrication approach to engineer complex living structures as the conventional fabrication methods are incapable of integrating structural and biological complexities. It offers the versatility of printing different cell incorporated hydrogels (bioink) layer by layer; offering control over spatial resolution and cell distribution to mimic native tissue architectures. However, the bioprinting of tough hydrogels involve additional complexities, such as employing complex crosslinking or reinforcing mechanisms during printing and pre/post printing cellular activities. Solving this complexity requires attention from engineering, material science and cell biology perspectives. In this review, we discuss different types of bioprinting techniques with focus on current state-of-the-art in bioink formulations and pivotal characteristics of bioinks for tough hydrogel printing. We discuss the scope of transition from 3D to 4D bioprinting and some of the advanced characterization techniques for in-depth understanding of the 3D printing process from the microstructural perspective, along with few specific applications and conclude with the future perspectives in biofabrication of hydrogels for tissue engineering applications.

中文翻译:

可生物印刷的坚韧水凝胶,用于组织工程应用。

生物印刷是一种工程化复杂居住结构的先进制造方法,因为传统的制造方法无法整合结构和生物复杂性。它提供了多层印刷不同细胞结合的水凝胶(生物墨水)的多功能性;提供对空间分辨率和细胞分布的控制,以模仿天然组织结构。然而,坚韧水凝胶的生物印刷涉及额外的复杂性,例如在印刷和印刷前/印刷后的细胞活动中采用复杂的交联或增强机制。解决这种复杂性需要从工程,材料科学和细胞生物学的角度进行关注。在这篇评论中 我们将讨论不同类型的生物印刷技术,重点是生物油墨配方中的最新技术以及用于强力水凝胶印刷的生物油墨的关键特性。我们讨论了从3D生物打印到4D生物打印的过渡范围以及一些先进的表征技术,以便从微观结构的角度深入了解3D打印过程,以及一些特定的应用,并总结了用于组织水凝胶的生物加工的未来观点工程应用。
更新日期:2020-04-25
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