Purpose

To visualize and quantify vascular networks in individuals with ocular surface squamous neoplasia (OSSN) through optical coherence tomography angiography (OCTA).

Method

Cross-sectional study of OSSN patients. Vascular networks were measured by OCTA in the epithelium and sub-epithelial space in the tumors, adjacent tissue, and in the contralateral eye. Vessel area density (VAD, percent of blood vessels within 2.14 mm²), was calculated for each location. Total tumor density (TTD, percent of blood vessels within the entire tumor) was calculated. VAD was assessed separately for corneal and conjunctival locations and compared.

Results

Fifteen patients with OSSN were included. The mean age was 61 ± 12 years and the majority were male (80%). The mean tumor area, volume, depth, and TTD were 28.0 ± 9.0 mm² (range, 10.9–39.7), 9.1 ± 4.1 mm³ (range, 3.4–18.8), 334 ± 125 μm (range, 177–571), and 33.2% ± 11.0% (range, 18.7–58.8), respectively. The VAD was highest within the tumor (28.9% ± 8.7%) followed by the adjacent sub-epithelial tissue and the tissue underneath the conjunctival component of tumor. These densities were higher than the VAD in the tissues of the non-involved eye (all P < 0.05). The VAD within conjunctival component of tumor was significantly higher than those with corneal component (29.8% ± 9.5% vs. 21.1% ± 5.5%, p = 0.006). The VAD under conjunctival tumor was also significantly higher than under corneal component (24.1% ± 7.8% vs. 17.0% ± 6.1%, p = 0.024).

Conclusions

OCTA imaging allowed for visualization and quantification of vessel structure and density within, under, and surrounding OSSN.

中文翻译：

---

光学相干断层扫描血管造影在眼表鳞状瘤形成血管网络模式表征中的作用。

目的

通过光学相干断层扫描血管造影 (OCTA) 可视化和量化眼表鳞状瘤 (OSSN) 患者的血管网络。

方法

OSSN 患者的横断面研究。通过 OCTA 在肿瘤、邻近组织和对侧眼中的上皮和上皮下空间中测量血管网络。计算每个位置的血管面积密度（VAD，2.14 mm ²内血管的百分比）。计算总肿瘤密度（TTD，整个肿瘤内血管的百分比）。VAD 分别评估角膜和结膜位置并进行比较。

结果

包括 15 名 OSSN 患者。平均年龄为 61 ± 12 岁，大多数为男性（80%）。平均肿瘤面积、体积、深度和 TTD 为 28.0 ± 9.0 mm ²（范围，10.9–39.7）、9.1 ± 4.1 mm ³（范围，3.4–18.8）、334 ± 125 μm（范围，177–571）和 33.2% ± 11.0%（范围，18.7–58.8）。VAD在肿瘤内最高（28.9%±8.7%），其次是邻近的上皮下组织和肿瘤结膜成分下方的组织。这些密度高于未受累眼组织中的 VAD（均 P < 0.05）。肿瘤结膜成分内的 VAD 显着高于角膜成分（29.8% ± 9.5% vs. 21.1% ± 5.5%，p = 0.006）。结膜肿瘤下的 VAD 也显着高于角膜成分下（24.1% ± 7.8% 对 17.0% ± 6.1%，p = 0.024）。

结论

OCTA 成像允许对 OSSN 内部、下方和周围的血管结构和密度进行可视化和量化。