Cancer is a global health problem and is one of the leading causes of death worldwide. Pleasingly, the rate of survival has improved and continues in an upward trend mainly due to better diagnosis and treatment modalities. In particular, the development of anticancer drugs including cytotoxic chemotherapy, hormonal agents and targeted therapies have provided the most effective treatment options in combatting cancerous cells. However, the antineoplastic mechanisms of these drugs can also lead to undesirable systemic and ocular side effects resulting from cytotoxicity, inflammation and neurotoxicity. While survival rates are projected to increase with time, the number of patients presenting with these side effects that can substantially impact quality of life will also rise. The current paper reviews the ocular surface and adnexal side effects of anticancer drugs, the appropriate management and possible interactions between drugs for ocular surface pathology treatment and the anticancer drugs.

癌症是全球性的健康问题，并且是全球范围内死亡的主要原因之一。令人欣慰的是，由于更好的诊断和治疗方式，存活率有所提高并继续呈上升趋势。尤其是，包括细胞毒性化学疗法，激素药物和靶向疗法在内的抗癌药物的开发为对抗癌细胞提供了最有效的治疗选择。但是，这些药物的抗肿瘤作用机制也可能导致由细胞毒性，炎症和神经毒性引起的不良全身和眼部副作用。尽管预计存活率会随着时间增加，但出现这些副作用的患者数量可能会大大影响生活质量，因此患者数量也会增加。