Phototherapy has the advantages of minimal invasion, few side effects, and improved accuracy for cancer therapy. The application of a polydopamine (PDA)‐modified nano zero‐valent iron (nZVI@PDA) as a new synergistic agent in combination with photodynamic/photothermal (PD/PT) therapy to kill cancer cells is discussed here. The nZVI@PDA offered high light‐to‐heat conversion and ROS generation efficiency under near‐infrared (NIR) irradiation (808 nm), thus leading to irreversible damage to nZVI@PDA‐treated MCF‐7 cells at low concentration, without inducing apoptosis in normal cells. Irradiation of nZVI@PDA using an NIR laser converted the energy of the photons to heat and ROS. Our results showed that modification of the PDA on the surface of nZVI can improve the biocompatibility of the nZVI@PDA. This work integrated the PD and PT effects into a single nanodevice to afford a highly efficient cancer treatment. Meanwhile, nZVI@PDA, which combines the advantages of PDA and nZVI, displayed excellent biocompatibility and tumoricidal ability, thus suggesting its huge potential for future clinical research in cancer therapy.

中文翻译：

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多巴胺修饰的零价铁纳米粒子用于双模式光热和光动力乳腺癌治疗。

光疗的优点是浸润最小，副作用少，提高了癌症治疗的准确性。此处讨论了聚多巴胺（PDA）修饰的纳米零价铁（nZVI @ PDA）作为新型协同剂与光动力/光热（PD / PT）治疗相结合杀死癌细胞的应用。nZVI @ PDA在近红外（NIR）辐照（808 nm）下提供了高的光热转换和ROS产生效率，因此对nZVI @ PDA处理过的MCF-7细胞在低浓度下产生了不可逆的损害，而不会引起正常细胞凋亡。使用NIR激光照射nZVI @ PDA将光子的能量转换为热量和ROS。我们的结果表明，在nZVI表面改性PDA可以改善nZVI @ PDA的生物相容性。这项工作将PD和PT效应整合到单个纳米装置中，以提供高效的癌症治疗。同时，结合了PDA和nZVI优点的nZVI @ PDA表现出优异的生物相容性和杀肿瘤能力，从而表明其在未来癌症治疗临床研究中的巨大潜力。