Phosphoantigens (pAgs) are small phosphorus‐containing molecules that stimulate Vγ9Vδ2 T cells with sub‐nanomolar cellular potency. Recent work has revealed that these compounds work through binding to the transmembrane immunoglobulin butyrophilin 3A1 (BTN3A1) within its intracellular B30.2 domain. Engagement of BTN3A1 is critical to the formation of an immune synapse between cells that contain pAgs and the Vγ9Vδ2 T cells. This minireview summarizes the structure‐activity relationships of pAgs and their implications to the mechanisms of butyrophilin 3 activation leading to Vγ9Vδ2 T cell response.

中文翻译：

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Butyrophilin 3配体的构效关系。

磷酸抗原（pAgs）是小的含磷分子，可以以亚纳摩尔级的细胞力刺激Vγ9Vδ2T细胞。最近的工作表明，这些化合物通过结合至其细胞内B30.2域内的跨膜免疫球蛋白酪氨酸3A1（BTN3A1）而起作用。BTN3A1的参与对于包含pAgs的细胞和Vγ9Vδ2T细胞之间免疫突触的形成至关重要。这篇小型综述总结了pAg的结构-活性关系及其对导致Vγ9Vδ2T细胞应答的butyrophilin 3激活机制的影响。