Cancer cells are confronted with nutrient deprivation because of high proliferation rate, especially at the early stage of their development. There is a frequent assumption that nutrient deprivation decreases the basal activity of cancer cells. Contrarily, there are recent evidence suggesting that cancer cells are able to modulate signaling pathways to adapt with new condition and continue their survival. This property of cancer cells is believed to be one of the prerequisites for cancer progression and chemoresistance. Moreover, recent experiments show that serum starvation in vitro as a mimic situation of nutrient deprivation in vivo triggers different signaling pathways leading to changes in cancer cell behavior, which may interfere with experimental results. Considering these facts, a better understanding of the effect of nutrient deprivation on cancer cell behavior will help us to give more accurate conclusions regarding results of in vitro studies and also to develop new strategies to treat different cancers in vivo.

中文翻译：

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营养剥夺下癌细胞行为的体外和体内研究。

癌细胞由于高增殖率而面临营养缺乏，特别是在其发展的早期。人们经常认为营养物质的缺乏会降低癌细胞的基础活性。相反，最近的证据表明癌细胞能够调节信号通路以适应新的疾病并继续其生存。癌细胞的这种性质被认为是癌症进展和化学抗性的先决条件之一。此外，最近的实验表明，体外血清饥饿作为体内营养剥夺的一种模拟情况，会触发不同的信号传导途径，导致癌细胞行为发生变化，这可能会干扰实验结果。考虑到这些事实，