Our study investigated the differences in pharmacokinetics of three major components of crude Cimicifuga foetida L. and its fried product and honey‐ and liquor‐prepared products. A rapid and sensitive ultra‐high performance liquid chromatography with tandem mass spectrometry approach was established for determing caffeic acid, isoferulic acid and ferulic acid in rat plasma. The approach has good linearity, precision, accuracy, recovery and stability. Phenolic acid was rapidly absorbed. The times to peak concentration were shorter in the processed group than those for the crude product, with their values of <30 min. The peak concentration values of caffeic acid and isoferulic acid were higher in the crude group than in the processed groups (p  < 0.05). Area under the curve values of the three phenolics in the crude group were significantly higher than those of the processed groups (p < 0.05).

中文翻译：

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粗品和三种不同制备的Cimicifuga foetida L中咖啡酸，异阿魏酸和阿魏酸的体内体内比较药代动力学研究。

我们的研究调查了粗Citicifuga foetida L.及其油炸产品以及蜂蜜和酒制产品的三个主要成分在药代动力学方面的差异。建立了一种快速灵敏的串联质谱超高效液相色谱法，用于测定大鼠血浆中的咖啡酸，异阿魏酸和阿魏酸。该方法具有良好的线性，精度，准确性，恢复性和稳定性。酚酸被迅速吸收。在处理组中，达到峰值浓度的时间比粗产品的时间短，其值小于30分钟。粗组中咖啡酸和异阿魏酸的峰值浓度高于加工组（p <0.05）。原油组中三种酚类化合物的曲线下面积均显着高于处理组（p < 0.05）。