ABSTRACT A group of noroxymorphone derivatives were subjected to Gewald reaction conditions to prepare their respective aminothieno products. In refluxing piperidine/ethanol, 1a–g reacted with elemental sulfur and malononitrile to produce 2a–g in high yields. Reactions took place in one pot and completed within 4–7 h and products precipitated spontaneously in the reaction mixtures. GRAPHICAL ABSTRACT

中文翻译：

---

应用 Gewald 反应制备一些具有去甲羟吗啡酮骨架的新型氨基噻吩衍生物

摘要 一组去甲羟吗啡酮衍生物在 Gewald 反应条件下制备它们各自的氨基噻吩并产物。在回流哌啶/乙醇中，1a-g 与元素硫和丙二腈反应以高产率生产 2a-g。反应在一锅中进行，并在 4-7 小时内完成，产物在反应混合物中自发沉淀。图形概要