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Applying Gewald reaction for the preparation of some novel aminothieno derivatives featuring noroxymorphone skeletal backbone
Journal of Sulfur Chemistry ( IF 2.1 ) Pub Date : 2020-02-19 , DOI: 10.1080/17415993.2020.1729761 Saeed Bagherpour 1 , Mohammad M. Mojtahedi 1 , M. Saeed Abaee 1
Journal of Sulfur Chemistry ( IF 2.1 ) Pub Date : 2020-02-19 , DOI: 10.1080/17415993.2020.1729761 Saeed Bagherpour 1 , Mohammad M. Mojtahedi 1 , M. Saeed Abaee 1
Affiliation
ABSTRACT A group of noroxymorphone derivatives were subjected to Gewald reaction conditions to prepare their respective aminothieno products. In refluxing piperidine/ethanol, 1a–g reacted with elemental sulfur and malononitrile to produce 2a–g in high yields. Reactions took place in one pot and completed within 4–7 h and products precipitated spontaneously in the reaction mixtures. GRAPHICAL ABSTRACT
中文翻译:
应用 Gewald 反应制备一些具有去甲羟吗啡酮骨架的新型氨基噻吩衍生物
摘要 一组去甲羟吗啡酮衍生物在 Gewald 反应条件下制备它们各自的氨基噻吩并产物。在回流哌啶/乙醇中,1a-g 与元素硫和丙二腈反应以高产率生产 2a-g。反应在一锅中进行,并在 4-7 小时内完成,产物在反应混合物中自发沉淀。图形概要
更新日期:2020-02-19
中文翻译:
应用 Gewald 反应制备一些具有去甲羟吗啡酮骨架的新型氨基噻吩衍生物
摘要 一组去甲羟吗啡酮衍生物在 Gewald 反应条件下制备它们各自的氨基噻吩并产物。在回流哌啶/乙醇中,1a-g 与元素硫和丙二腈反应以高产率生产 2a-g。反应在一锅中进行,并在 4-7 小时内完成,产物在反应混合物中自发沉淀。图形概要