ABSTRACT A new synthesis of novel 1,3-difunctionalized 2-aminopropane derivatives from N-sulfonylated aziridines is described. The reaction of 2-(bromomethyl)-1-sulfonylaziridines with substituted thiourea and arylthiol derivatives in presence MeONa in DMF at 35–40°C occurs readily to afford 2-(alkyl/arylsulfonamido)-1,3-diyl-bis(N′-phenylcarbamimidothioate) and N-(1,3-bis(arylthio)propan-2-yl)-arylsulfonamide compounds in good yields. GRAPHICAL ABSTRACT

中文翻译：

---

通过取代硫脲和芳硫醇衍生物与 N-磺酰化氮丙啶反应合成 1,3-双官能化 2-氨基丙烷衍生物

摘要描述了一种从 N-磺酰化氮丙啶合成新型 1,3-双官能化 2-氨基丙烷衍生物的新方法。2-(溴甲基)-1-磺酰氮丙啶与取代的硫脲和芳硫醇衍生物在 MeONa 存在下在 DMF 中在 35–40°C 下反应容易发生，得到 2-(烷基/芳基磺酰胺)-1,3-二基-双(N '-苯基氨基甲亚氨基硫酸酯)和 N-(1,3-双(芳硫基)丙-2-基)-芳基磺酰胺化合物的产率良好。图形概要