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Chemogenetic Activation of Glutamatergic Neurons in the Juvenile Rat Cortex Reduces Anxiety.
Doklady Biochemistry and Biophysics ( IF 0.8 ) Pub Date : 2020-04-27 , DOI: 10.1134/s1607672920010056
N N Dygalo 1, 2 , D A Lanshakov 1 , N P Komysheva 1 , U S Drozd 1, 2 , E V Shaburova 1, 2 , E V Sukhareva 1, 2 , G T Shishkina 1
Affiliation  

Abstract—Chemogenetic activation of glutamatergic neurons of the prefrontal cortex reduces the manifestations of psychoemotional anxiety during the juvenile period of ontogenesis. This result is the first evidence of feasibility of targeted chemogenetic control of neuronal activity during the early stages of brain development.

中文翻译:

幼年大鼠皮层中谷氨酸能神经元的化学遗传激活减少了焦虑。

摘要—额叶前额叶皮层的谷氨酸能神经元的化学遗传激活减少了成年少年时期心理情绪焦虑的表现。该结果是在脑发育早期对神经元活动进行靶向化学生成控制的可行性的第一个证据。
更新日期:2020-04-27
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