Background: Cerebral small vessel disease (CSVD) is associated with future stroke. Although pathological alteration in small vessels of patients with CSVD can be detected by neuroimaging, diagnosis of CSVD is delayed because it is an asymptomatic disease. The stroke-prone spontaneously hypertensive rat (SHRSP) show similar pathological features to human CSVD and develop stroke-related symptoms with advancing age.Objective: We investigated the time course of haematological parameters in Wistar rats and SHRSP.Material and Methods: Blood cells were analysed using an automated haematological analyser.Results: SHRSP develop stroke-related symptoms including onset of neurological symptoms, decreased body weight and blood brain barrier leakage between 12 and 14 weeks of age. Lymphocyte counts were gradually decreased at 3 weeks before development of stoke-related symptoms and then were further decreased after the development of stroke-related symptoms. The both mean platelet volume and large platelet ratio gradually increased at 3 weeks before the development of stoke-related symptoms. However, although SHRSP showed more microcytic red cells than Wistar rats, the trajectories of change in erythrocyte-related parameters were similar between Wistar rats and SHRSP.Conclusion: Our pilot study suggests that alterations of lymphocyte count and platelet volume predictive indicators for asymptomatic CSVD and symptomatic stroke in SHRSP.

中文翻译：

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在易中风的自发性高血压大鼠中，脑血管病变之前淋巴细胞计数和血小板量的变化。

背景：脑小血管疾病（CSVD）与未来中风有关。尽管可以通过神经影像学检查来检测CSVD患者小血管的病理改变，但由于CSVD是无症状疾病，因此诊断被延迟。中风倾向性自发性高血压大鼠（SHRSP）与人类CSVD表现出相似的病理特征，并随着年龄的增长而出现中风相关症状。目的：研究Wistar大鼠和SHRSP血液学参数的时程。结果：SHRSP在12至14周龄之间出现中风相关症状，包括神经系统症状发作，体重下降和血脑屏障渗漏。卒中相关症状发生前3周，淋巴细胞计数逐渐降低，而卒中相关症状出现后，淋巴细胞计数进一步降低。在卒中相关症状出现前3周，平均血小板体积和大血小板比率均逐渐增加。然而，尽管SHRSP的微细胞红细胞数量多于Wistar大鼠，但Wistar大鼠与SHRSP的红细胞相关参数变化轨迹相似。结论：我们的初步研究表明，无症状CSVD和淋巴细胞的淋巴细胞计数和血小板体积预测指标的改变SHRSP中的症状性中风。在卒中相关症状出现前3周，平均血小板体积和大血小板比例均逐渐增加。然而，尽管SHRSP的微细胞红细胞数量多于Wistar大鼠，但Wistar大鼠与SHRSP的红细胞相关参数变化轨迹相似。结论：我们的初步研究表明，无症状CSVD和淋巴细胞的淋巴细胞计数和血小板体积预测指标的改变SHRSP中的症状性中风。在卒中相关症状出现前3周，平均血小板体积和大血小板比例均逐渐增加。然而，尽管SHRSP的微细胞红细胞数量多于Wistar大鼠，但Wistar大鼠与SHRSP的红细胞相关参数变化轨迹相似。结论：我们的初步研究表明，无症状CSVD和淋巴细胞的淋巴细胞计数和血小板体积预测指标的改变SHRSP中的症状性中风。