Rhomboid intramembrane serine proteases are present in all kingdoms of life, but as we do not know their substrates in many species, it remains puzzling why rhomboids are among the most-conserved integral membrane proteins. Two new studies in The EMBO Journal by Began et al and Liu et al now link bacterial rhomboid proteases to membrane protein degradation, showing striking similarities to what is known about eukaryotic rhomboid family proteins, thus pointing toward a conserved membrane surveillance mechanism.

中文翻译：

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带剪刀的Derlins：细菌中的原始ERAD。

菱形膜内丝氨酸蛋白酶存在于所有生命的王国中，但是由于我们不知道它们在许多物种中的底物，所以仍然困惑为什么菱形蛋白是最保守的整体膜蛋白之一。Began等人和Liu等人在《 EMBO杂志》上的两项新研究现在将细菌菱形蛋白酶与膜蛋白降解联系起来，显示出与真核菱形家族蛋白已知的惊人相似之处，从而指出了保守的膜监测机制。