Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we explore the growing importance of Huwe1 in nervous system development, function and disease. We discuss extensive progress made in deciphering how Huwe1 regulates neural progenitor proliferation and differentiation, cell migration, and axon development. We highlight recent evidence indicating that Huwe1 regulates inhibitory neurotransmission. In covering these topics, we focus on findings made using both vertebrate and invertebrate in vivo model systems. Finally, we discuss extensive human genetic studies that strongly implicate HUWE1 in intellectual disability, and heighten the importance of continuing to unravel how Huwe1 affects the nervous system.

中文翻译：

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HUWE1 泛素连接酶在神经系统发育、功能和疾病中的作用。

Huwe1 是 HECT E3 泛素连接酶家族的一个高度保守的成员。在这里，我们探讨 Huwe1 在神经系统发育、功能和疾病中日益增长的重要性。我们讨论了在破译 Huwe1 如何调节神经祖细胞增殖和分化、细胞迁移和轴突发育方面取得的广泛进展。我们强调最近的证据表明 Huwe1 调节抑制性神经传递。在涵盖这些主题时，我们重点关注使用脊椎动物和无脊椎动物体内模型系统所做的发现。最后，我们讨论了广泛的人类遗传研究，这些研究强烈暗示 HUWE1 与智力障碍有关，并强调了继续阐明 Huwe1 如何影响神经系统的重要性。