Metal–Organic Framework Composites for Theragnostics and Drug Delivery Applications,Biotechnology Journal

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Metal–Organic Framework Composites for Theragnostics and Drug Delivery Applications
Biotechnology Journal ( IF 3.2 ) Pub Date : 2020-04-24 , DOI: 10.1002/biot.202000005
Johannes W M Osterrieth ₁ , David Fairen-Jimenez ₁

Affiliation

Among a plethora of nano‐sized therapeutics, metal‐organic frameworks (MOFs) have been some of the most investigated novel materials for, predominantly, cancer drug delivery applications. Due to their large drug uptake capacities and slow‐release mechanisms, MOFs are desirable drug delivery vehicles that protect and transport sensitive drug molecules to target sites. The inclusion of other guest materials into MOFs to make MOF‐composite materials has added further functionality, from externally triggered drug release to improved pharmacokinetics and diagnostic aids. MOF‐composites are synthetically versatile and can include examples such as magnetic nanoparticles in MOFs for MRI image contrast and polymer coatings that improve the blood‐circulation time. From synthesis to applications, this review will consider the main developments in MOF‐composite chemistry for biomedical applications and demonstrate the potential of these novel agents in nanomedicine. It is concluded that, although vast synthetic progress has been made in the field, it requires now to develop more biomedical expertise with a focus on rational model selection, a major comparative toxicity study, and advanced targeting techniques.

中文翻译：

金属-有机骨架复合材料，用于矫正术和药物递送应用

在众多的纳米尺寸治疗剂中，金属有机骨架（MOF）已经成为研究最多的新颖材料，主要用于癌症药物递送应用。由于具有强大的药物吸收能力和缓释机制，MOF是理想的药物输送工具，可保护敏感的药物分子并将其运输至目标部位。从MOF中添加其他客体材料以制成MOF复合材料，从外部触发的药物释放到改善的药代动力学和诊断辅助工具，都增加了更多功能。MOF复合材料在合成上具有多种用途，可以包括例如用于MRI图像对比的MOF中的磁性纳米颗粒和可改善血液循环时间的聚合物涂层。从综合到应用，这篇综述将考虑MOF复合化学在生物医学应用中的主要发展，并论证这些新型药物在纳米医学中的潜力。结论是，尽管在该领域已取得了巨大的合成进展，但现在需要发展更多的生物医学专业知识，重点是合理的模型选择，主要的比较毒性研究和先进的靶向技术。

更新日期：2020-04-24

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