Bioglass nanoparticles (n‐BGs, 54SiO₂:40CaO:6P₂O₅ mol %) with about 27 nm diameter were synthesized by the sol–gel method and incorporated into a poly(lactic acid) (PLA) matrix by the melting process in order to obtain nanocomposites with filler contents of 5, 10, and 25 wt %. Our results showed that during the cooling scan, the crystallization temperature (T_c) of the PLA/n‐BG nanocomposites decreased 13°C as compared to neat PLA. The presence of nanoparticles also decreased the thermal stability of the PLA matrix, as nanocomposites presented up to about 20°C lower degradation temperatures in a nitrogen atmosphere. The presence of n‐BG increased the stiffness of the polymer matrix, and for instance the composite with 25 wt % of filler presented about 52.6% higher Young's modulus than neat PLA. n‐BG incorporation into PLA increased also the hydrolytic degradation of the polymer over time. When the PLA composites were immersed in simulated body fluid, an apatite layer was formed on their surface, as verified by Fourier transform infrared, X‐Ray Diffraction (XRD), and scanning electron microscopy‐EDS, showing that the presence of n‐BG induced bioactivity on the PLA matrix. Moreover, the viability of cervical uterine adenocarcinoma cells was higher on PLA/n‐BG nanocomposite with 25 wt % of filler. The presence of n‐BG barely gave an antibacterial effect on the polymer matrix, despite the well‐known biocidal properties of these nanoparticles. Our results show that the presence of n‐BGs is a proper route for improving the bioactivity of PLA with potential application in tissue engineering.

中文翻译：

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生物玻璃纳米颗粒对聚乳酸薄膜性能和生物活性的影响。

通过溶胶-凝胶法合成直径约 27 nm 的生物玻璃纳米粒子（n-BGs，54SiO ₂ :40CaO:6P ₂ O ₅ mol%），并通过熔化过程将其掺入聚乳酸（PLA）基质中为了获得填料含量为 5、10 和 25 重量％的纳米复合材料。我们的结果表明，在冷却扫描过程中，结晶温度（T _c) 的 PLA/n-BG 纳米复合材料与纯 PLA 相比降低了 13°C。纳米颗粒的存在也降低了 PLA 基质的热稳定性，因为纳米复合材料在氮气氛中的降解温度降低了约 20°C。n-BG 的存在增加了聚合物基体的刚度，例如，具有 25 wt% 填料的复合材料的杨氏模量比纯 PLA 高约 52.6%。随着时间的推移，将 n-BG 掺入 PLA 也会增加聚合物的水解降解。当 PLA 复合材料浸入模拟体液中时，其表面形成磷灰石层，如傅里叶变换红外、X 射线衍射 (XRD) 和扫描电子显微镜-EDS 所证实，表明 n-BG 的存在在 PLA 基质上诱导生物活性。而且，含有 25 wt% 填料的 PLA/n-BG 纳米复合材料的宫颈子宫腺癌细胞的活力更高。尽管这些纳米颗粒具有众所周知的杀生物特性，但 n-BG 的存在几乎不会对聚合物基质产生抗菌作用。我们的结果表明，n-BGs 的存在是提高 PLA 生物活性的合适途径，具有在组织工程中的潜在应用。