We compared resting state (RS) functional connectivity and task‐based fMRI to lateralize language dominance in 30 epilepsy patients (mean age = 33; SD = 11; 12 female), a measure used for presurgical planning. Language laterality index (LI) was calculated from task fMRI in frontal, temporal, and frontal + temporal regional masks using LI bootstrap method from SPM12. RS language LI was assessed using two novel methods of calculating RS language LI from bilateral Broca's area seed based connectivity maps across regional masks and multiple thresholds (p  < .05, p  < .01, p  < .001, top 10% connections). We compared LI from task and RS fMRI continuous values and dominance classifications. We found significant positive correlations between task LI and RS LI when functional connectivity thresholds were set to the top 10% of connections. Concordance of dominance classifications ranged from 20% to 30% for the intrahemispheric resting state LI method and 50% to 63% for the resting state LI intra‐ minus interhemispheric difference method. Approximately 40% of patients left dominant on task showed RS bilateral dominance. There was no difference in LI concordance between patients with right‐sided and left‐sided resections. Early seizure onset (<6 years old) was not associated with atypical language dominance during task‐based or RS fMRI. While a relationship between task LI and RS LI exists in patients with epilepsy, language dominance is less lateralized on RS than task fMRI. Concordance of language dominance classifications between task and resting state fMRI depends on brain regions surveyed and RS LI calculation method.

中文翻译：

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癫痫患者基于任务和静息状态功能 MRI 的语言偏侧化。

我们比较了 30 名癫痫患者（平均年龄 = 33；SD = 11；12 名女性）的静息状态 (RS) 功能连通性和基于任务的 fMRI 以偏侧化语言优势，这是一种用于术前计划的衡量标准。语言偏侧性指数 (LI) 是使用 SPM12 的 LI 引导方法从额叶、颞叶和额叶 + 颞叶区域掩膜中的任务 fMRI 计算的。RS 语言 LI 使用两种新方法来评估 RS 语言 LI，这些方法从双边 Broca 区域种子跨越区域掩码和多个阈值的连接图计算 RS 语言 LI ( p  < .05, p  < .01, p < .001，前 10% 的连接）。我们比较了来自任务和 RS fMRI 连续值和优势分类的 LI。当功能连接阈值设置为连接的前 10% 时，我们发现任务 LI 和 RS LI 之间存在显着的正相关。半球内静息状态 LI 方法的优势分类一致性范围为 20% 至 30%，而静息状态 LI 半球内减去半球间差异方法为 50% 至 63%。大约 40% 在任务中保持优势的患者显示 RS 双侧优势。右侧和左侧切除患者的 LI 一致性没有差异。早期癫痫发作（<6 岁）与基于任务或 RS fMRI 期间的非典型语言优势无关。虽然在癫痫患者中存在任务 LI 和 RS LI 之间的关系，与任务 fMRI 相比，RS 上的语言优势较少偏侧化。任务和静息状态 fMRI 之间语言优势分类的一致性取决于调查的大脑区域和 RS LI 计算方法。