Nitric oxide production inhibitory eudesmane‐type sesquiterpenoids from Artemisia argyi,Chemistry & Biodiversity

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Nitric oxide production inhibitory eudesmane‐type sesquiterpenoids from Artemisia argyi
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-06-23 , DOI: 10.1002/cbdv.202000238
Lai-Bin Zhang ₁ , Xiao-Na Nie ₁ , Jia-Jing Chang ₁ , Feng-Long Wang ₁ , Jie-Li Lü ₁

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Six new eudesmane‐type sesquiterpene derivatives, artemargyinins A–F were isolated from the leaves of Artemisia argyi. Their structures were elucidated based on the extensive analysis of spectroscopic data. Artemargyinins A–F feature a lactone ring‐opening eudesmane‐type sesquiterpene with an isoprenoid group at C(8). All compounds were tested for their inhibitory effects on lipopolysaccharide‐induced nitric oxide (NO) production in RAW264.7 macrophages. Artemargyinins A–F showed more potent NO production inhibitory activity with IC50 values ranging from 7.66±0.53 to 61.19±2.54 μM than the positive control quercetin (IC50=74.34±1.39 μM). Among them, artemargyinins C and D exhibited strong inhibitory activity with IC50 values of 8.08±0.21 and 7.66±0.53 μM, respectively.

中文翻译：

来自艾蒿的抑制一氧化氮产生的eudesmane型倍半萜类化合物

从艾蒿的叶子中分离出六种新的eudesmane型倍半萜烯衍生物，青蒿素A-F。基于对光谱数据的广泛分析，阐明了它们的结构。青蒿素 A-F 具有内酯开环 eudesmane 型倍半萜烯，在 C(8) 处具有类异戊二烯基团。测试了所有化合物对 RAW264.7 巨噬细胞中脂多糖诱导的一氧化氮 (NO) 产生的抑制作用。Artemargyinins A-F 显示出更强的 NO 产生抑制活性，IC50 值范围为 7.66±0.53 至 61.19±2.54 μM，比阳性对照槲皮素（IC50=74.34±1.39 μM）。其中，青蒿素C和D表现出很强的抑制活性，IC50值分别为8.08±0.21和7.66±0.53 μM。

更新日期：2020-06-23

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