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Glycosylation as a tool for rational vaccine design.
Biotechnology and Bioengineering ( IF 3.5 ) Pub Date : 2020-04-24 , DOI: 10.1002/bit.27361 Vivek Hariharan 1 , Ravi S Kane 1
Biotechnology and Bioengineering ( IF 3.5 ) Pub Date : 2020-04-24 , DOI: 10.1002/bit.27361 Vivek Hariharan 1 , Ravi S Kane 1
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The discovery of broadly neutralizing antibodies that can neutralize multiple strains or subtypes of a pathogen has renewed interest in the development of broadly protective vaccines. To that end, there has been an interest in designing immunofocusing strategies to direct the immune response to specific, conserved regions on antigenic proteins. Modulation of glycosylation is one such immunofocusing strategy; extensive glycosylation is often exploited by pathogens for immune evasion. Masking epitopes on protein immunogens with “self” glycans can also shield the underlying protein surface from humoral immune surveillance. We review recent advances in applying glycosylation as an immunofocusing tool. We also highlight recent interesting work in the HIV‐1 field involving the identification and elicitation of broadly neutralizing antibodies that incorporate glycans into their binding epitopes.
中文翻译：
糖基化作为合理疫苗设计的工具。
可以中和病原体的多种菌株或亚型的广泛中和抗体的发现重新引起了人们对开发广泛保护性疫苗的兴趣。为此，人们对设计免疫聚焦策略以将免疫反应引导至抗原蛋白上的特定保守区域产生兴趣。糖基化的调节就是这样一种免疫聚焦策略；病原体经常利用广泛的糖基化来逃避免疫。用“自身”聚糖掩盖蛋白质免疫原上的表位也可以保护潜在的蛋白质表面免受体液免疫监视。我们回顾了应用糖基化作为免疫聚焦工具的最新进展。
更新日期：2020-04-24
中文翻译：
糖基化作为合理疫苗设计的工具。
可以中和病原体的多种菌株或亚型的广泛中和抗体的发现重新引起了人们对开发广泛保护性疫苗的兴趣。为此，人们对设计免疫聚焦策略以将免疫反应引导至抗原蛋白上的特定保守区域产生兴趣。糖基化的调节就是这样一种免疫聚焦策略；病原体经常利用广泛的糖基化来逃避免疫。用“自身”聚糖掩盖蛋白质免疫原上的表位也可以保护潜在的蛋白质表面免受体液免疫监视。我们回顾了应用糖基化作为免疫聚焦工具的最新进展。
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