With the development of photodynamic therapy (PDT), remarkable studies have been conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of chemical modifications of the porphyrin skeleton have been introduced to improve cellular delivery, stability, and selectivity for cancerous tissues. This review aims to highlight the developments in porphyrin-based structural modifications, with a specific emphasis on the role of PDT in anticancer treatment and the design of PSs to achieve a synergistic effect on multiple targets.

中文翻译：

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增强基于卟啉骨架的光动力疗法的化学方法。


随着光动力疗法（PDT）的发展，人们对产生光敏剂（PS），特别是卟啉PS进行了引人注目的研究。人们对卟啉骨架进行了多种化学修饰，以改善癌组织的细胞递送、稳定性和选择性。本综述旨在重点介绍基于卟啉的结构修饰的进展，特别强调 PDT 在抗癌治疗中的作用以及 PS 的设计以实现对多个靶点的协同作用。