Inaccuracy localization and intrinsic radioresistance of solid tumors seriously hindered the clinical implementation of radiotherapy. In this study, we fabricated hyaluronic acid-functionalized gadolinium oxide nanoparticles (HA-Gd2O3 NPs) via one-pot hydrothermal process for effective magnetic resonance (MR) imaging and radiosensitization of tumors. By virtue of HA functionalization, the as-prepared HA-Gd2O3 NPs with a diameter of 105 nm showed favorable dispersibility in water, low cytotoxicity, and excellent biocompatibility and readily entered into the cytoplasm of cancer cells by HA receptor-mediated endocytosis. Importantly, HA-Gd2O3 NPs exhibited high longitudinal relaxivity (r1) 6.0 mM-1S-1 as MRI contrast agents and radiosensitization enhancement in a dose-dependent manner. These finds demonstrated that as-synthesized HA-Gd2O3 NPs as bifunctional theranostic agents have great potential in tumors diagnosis and radiotherapy.

中文翻译：

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透明质酸功能化的氧化d纳米粒子在磁共振成像引导下的肿瘤放射治疗。

实体瘤的定位不准确和固有的放射抗性严重阻碍了放射治疗的临床实施。在这项研究中，我们通过一锅水热法制备了透明质酸官能化的氧化oxide纳米粒子（HA-Gd2O3 NPs），以进行有效的磁共振（MR）成像和肿瘤放射增敏。借助于HA功能化，所制备的直径为105nm的HA-Gd 2 O 3 NP显示出在水中的有利分散性，低细胞毒性和优异的生物相容性，并且易于通过HA受体介导的内吞作用进入癌细胞的细胞质。重要的是，HA-Gd2O3 NPs具有较高的纵向弛豫性（r1）6.0 mM-1S-1作为MRI造影剂，并且以剂量依赖的方式增强了放射增敏作用。