The association of proteins with metals, metalation, is challenging because the tightest binding metals are rarely the correct ones. Inside cells, correct metalation is enabled by controlled bioavailability plus extra mechanisms for tricky combinations such as iron and manganese.

中文翻译：

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金属化：生物无机化学中自然的挑战。

蛋白质与金属的结合（金属化）具有挑战性，因为结合最紧密的金属很少是正确的金属。在细胞内部，通过控制生物利用度以及用于棘手组合（例如铁和锰）的额外机制，可以实现正确的金属化。