Depression and anxiety are comorbid conditions in many neurological or psychopathological disorders. Stress is an underlying event that triggers development of anxiety and depressive-like behaviors. Recent experimental data indicate that anxiety and depressive-like behaviors occurring as a result of stressful situations can cause blood–brain barrier (BBB) dysfunction, which is characterized by inflammation and leakage. However, the underlying mechanisms are not completely understood. This paper sought to review recent experimental preclinical and clinical data that suggest possible molecular mechanisms involved in development of stress-induced anxiety and depression with associated BBB inflammation and leakage. Critical therapeutic targets and potential pharmacological candidates for treatment of stress-induced anxiety and depression with associated BBB dysfunctions are also discussed.

中文翻译：

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应激诱导的焦虑，抑郁和血脑屏障炎症和渗漏的细胞机制和分子信号通路。

抑郁和焦虑症是许多神经系统疾病或精神病理疾病的合并症。压力是触发焦虑和抑郁样行为发展的潜在事件。最近的实验数据表明，由于压力引起的焦虑和抑郁样行为会导致血脑屏障功能障碍，其特征是炎症和渗漏。但是，潜在的机制尚未完全理解。本文试图回顾最近的临床前临床和临床实验数据，这些数据提示可能与应激相关的焦虑和抑郁相关的血脑屏障发炎和渗漏发展的分子机制。