Salmonella enterica is an important gastrointestinal and facultative intracellular pathogen. After invasion of host cells, it resides in a specialized, replication-permissive compartment, the Salmonella-containing vacuole (SCV). During maturation of the SCV, Salmonella remodels the host endosomal system to form a variety of membranous extensions from the SCV, one type designated Salmonella-induced filaments (SIFs). It was long unclear how Salmonella is able to sustain replication within the SCV, thought to be a nutrient-poor environment. Recent studies started to characterize the metabolic pathways used by intracellular Salmonella. Besides, new insights into the ultrastructure and biogenesis of SIFs and their essential role in nutrition were obtained lately. Here, we review the recent progress with focus on observations gained by various cellular models.

肠沙门氏菌是重要的胃肠道和兼性细胞内病原体。入侵宿主细胞后，它位于一个专门的，允许复制的隔室中，即含有沙门氏菌的液泡（SCV）。在SCV成熟期间，沙门氏菌会重塑宿主的内体系统，从SCV形成多种膜状延伸，一种称为沙门氏菌诱导的细丝（SIF）。沙门氏菌如何能够维持SCV（被认为是营养不良的环境）内的复制，一直以来尚不清楚。最近的研究开始表征细胞内沙门氏菌使用的代谢途径。此外，最近获得了关于SIFs的超微结构和生物发生及其在营养中的重要作用的新见解。在这里，我们重点关注各种细胞模型获得的观察结果，回顾最近的进展。