The effect of hydroalcoholic Berberis integerrima fruits extract on the lipid profile, antioxidant parameters and liver and kidney function tests in patients with nonalcoholic fatty liver disease.,Saudi Journal of Biological Sciences

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The effect of hydroalcoholic Berberis integerrima fruits extract on the lipid profile, antioxidant parameters and liver and kidney function tests in patients with nonalcoholic fatty liver disease.
Saudi Journal of Biological Sciences Pub Date : 2020-04-25 , DOI: 10.1016/j.sjbs.2020.04.037
Mehdi Afsharinasab _{1,

2} , Maryam Mohammad-Sadeghipour _{1,

2,

3} , Mohammad Reza Hajizadeh _{1,

2} , Alireza Khoshdel ₄ , Vahid Mirzaiey ₅ , Mehdi Mahmoodi ₃

Affiliation

Background

Non-alcoholic fatty liver disease (NAFLD) is one of the hepatic disorders which is characterized by increasing fat deposits in the liver. This disorder may lead to elevation the activity of liver enzymes and is associated with obesity, dyslipidemia, hypertension, and type II diabetes. The aim of present study was to investigate the effect of Berberis integerrima extract on NAFLD patients compare to placebo.

Methods

The present clinical trial was performed on 42 NAFLD patients who were randomly divided into two groups. The case group received a capsule (750 mg) containing hydro-alcoholic extract of Berberis integerrima extract every 12 h for 2 months, while the control (placebo) group received a capsule containing cellulose. Baseline characteristics, biochemical factors, antioxidant parameter, functional liver and renal test were evaluated before and after the treatment.

Results

Comparison rate of different parameters in case group before and after treatment demonstrated that BMI, cholesterol, triglyceride, LDL-C, fasting blood glucose, liver enzymes and renal parameters such as aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were significantly decreased while HDL-C, glutathione peroxidase enzyme, and total antioxidant capacity were significantly elevated. The comparison of the mean parameters difference in two groups indicated that cholesterol, triglyceride, LDL-C, fasting blood glucose, liver enzymes and renal factors were significantly decreased, however HDL-C, glutathione peroxidase enzyme, and total antioxidant capacity were significantly increased in case group compared to control group.

Conclusion

The study findings revealed that the Berberis integerrima extract could reduce biochemical factors of blood, except HDL-C and increases total antioxidant capacity and glutathione peroxidase enzyme. Therefore, hydro-alcoholic extract of Berberis integerrima may be used as a great supplementary medicine in treating NAFLD.

中文翻译：

水醇小檗果实提取物对非酒精性脂肪肝患者血脂、抗氧化参数和肝肾功能测试的影响。

背景

非酒精性脂肪性肝病 (NAFLD) 是一种肝脏疾病，其特征是肝脏中脂肪沉积增加。这种疾病可能导致肝酶活性升高，并与肥胖、血脂异常、高血压和 II 型糖尿病有关。本研究的目的是研究与安慰剂相比，小檗提取物对 NAFLD 患者的影响。

方法

目前的临床试验是对 42 名 NAFLD 患者进行的，他们被随机分为两组。病例组每 12 小时服用一粒含小檗水醇提取物的胶囊（750 mg），持续 2 个月，而对照组（安慰剂）组服用一粒含纤维素的胶囊。治疗前后评价基线特征、生化因素、抗氧化参数、肝肾功能试验。

结果

病例组治疗前后不同参数的比较率显示，BMI、胆固醇、甘油三酯、LDL-C、空腹血糖、肝酶和肾脏参数如天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、碱性磷酸酶显着降低，而HDL- C、谷胱甘肽过氧化物酶和总抗氧化能力显着升高。两组平均参数差异比较表明，胆固醇、甘油三酯、LDL-C、空腹血糖、肝酶和肾脏因子显着降低，而HDL-C、谷胱甘肽过氧化物酶和总抗氧化能力显着升高。病例组与对照组相比。