Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on SARS-CoV-2 at concentrations compatible with that obtained in human lung.

中文翻译：

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羟氯喹和阿奇霉素联合治疗 SARS-CoV-2 的体外试验显示出协同作用。

人类冠状病毒 SARS-CoV-2 于 2019 年底出现，并导致了高发病率和高死亡率的大流行。由于目前没有针对这种病毒的有效药物，药物再利用是一种以低成本治疗数百万感染患者的短期策略。羟氯喹在体外显示出抗病毒作用。它在体内显示出疗效，尤其是在初步临床试验中与阿奇霉素联合使用时。在这里，我们证明了羟氯喹和阿奇霉素的组合在体外对 SARS-CoV-2 具有协同作用，其浓度与人肺中获得的浓度相容。