Previously we showed that contamination of SH-SY5Y neuroblastoma cells by Mycoplasma hyorhinis strains NDMh and MCLD leads to increased levels of calpastatin (the endogenous, specific inhibitor of the Ca2+-dependent protease calpain), resulting in inhibition of calpain activation. We have found that the increased calpastatin level is promoted by the lipoprotein fraction (MhLpp) of the mycoplasmal membrane. Here we present MhLpp-based novel synthetic lipopeptides that induce upregulation of calpastatin in SH-SY5Y neuroblastoma cells, leading to protection of the treated cells against Ca2+/amyloid-β-peptide toxicity. These lipopeptides present a new class of promising agents against calpain-induced cell toxicity.

中文翻译：

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源自Mycoplasma hyorhinis的新型合成脂肽在SH-SY5Y神经母细胞瘤细胞中上调钙抑素并诱导抗淀粉样β-肽毒性的神经保护作用。

先前我们显示，支原体菌株NDMh和MCLD对SH-SY5Y神经母细胞瘤细胞的污染导致钙蛋白酶抑制素（Ca2 +依赖性蛋白酶钙蛋白酶的内源性特异性抑制剂）水平升高，从而导致钙蛋白酶活化的抑制。我们发现增加的钙蛋白酶抑素水平是由支原体膜的脂蛋白部分（MhLpp）促进的。在这里，我们介绍基于MhLpp的新型合成脂肽，其诱导SH-SY5Y神经母细胞瘤细胞中钙蛋白酶抑制素的上调，从而导致所处理的细胞免受Ca2 + /淀粉样β-肽毒性的影响。这些脂肽提供了针对钙蛋白酶诱导的细胞毒性的一类新的有前途的药物。