Dr Mariana F. Wolfner is the Goldwin Smith Professor of Molecular Biology and Genetics at Cornell University. After finishing her undergraduate studies at Cornell University in 1974, she went to Stanford University to pursue her PhD with Dr David Hogness. Following postdoc training in Bruce Baker’s lab at the University of California, San Diego, she joined the faculty at Cornell University in 1983. Over the past 37 years, Dr Wolfner has investigated two important topics in Reproductive Biology—the physiological functions of seminal fluid proteins and the egg to embryo transition. Her lab has identified over 200 seminal fluid proteins and characterized their physiological functions in Drosophila using a wide variety of molecular biological and genetic technologies. Her lab discovered that seminal proteins are essential for fertility and that they play important roles in chemical communication between animals in reproduction and behavior, as well as in evolutionary phenomena such as sexual selection and “arms races.” Her work on the egg to embryo transition has also unveiled many fundamental mechanisms, including calcium influx during egg activation, protein phosphorylation, and mRNA polyadenylation and stability control immediately after egg activation. Dr Wolfner has published ~200 original research articles, reviews, and book chapters, and she is a frequent invited speaker at meetings and conferences. Her prolific career has been recognized by numerous awards, her election as an AAAS Fellow in 2006 and her induction into the National Academy of Sciences in 2019. With great interest and respect, I interviewed Dr. Wolfner.

中文翻译：

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Mariana Wolfner博士访谈

Mariana F. Wolfner博士是康奈尔大学（Cornell University）戈德温·史密斯（Goldwin Smith）分子生物学和遗传学教授。在1974年完成了康奈尔大学的本科学习后，她去了斯坦福大学攻读David Hogness博士的博士学位。在加州大学圣地亚哥分校的布鲁斯·贝克实验室进行博士后培训后，她于1983年加入康奈尔大学。在过去的37年中，沃尔夫纳博士研究了生殖生物学中的两个重要主题-精液蛋白的生理功能鸡蛋向胚胎过渡。她的实验室已经鉴定出200多种精液蛋白，并使用多种分子生物学和遗传技术对其果蝇的生理功能进行了表征。她的实验室发现，精子蛋白对于生育是必不可少的，它们在动物之间生殖和行为的化学交流以及诸如性选择和“军备竞赛”等进化现象中起着重要作用。她在从卵子到胚胎的转变方面的工作也揭示了许多基本机制，包括卵子活化过程中钙的流入，蛋白质磷酸化以及卵子活化后立即进行mRNA聚腺苷酸化和稳定性控制。沃尔夫纳博士发表了约200篇原创研究文章，评论和书籍章节，她经常在会议上演讲。她的多产的职业生涯已经被无数奖项的认可，她当选为美国科学促进会的研究员在2006年和她感应到的科学在2019年的美国国家科学院有了极大的兴趣和尊重，