Comparative studies struggle with the challenge of balancing technical properties with the requirement of obtaining samples from multiple species. Guidelines are needed to minimize the effect of confounders and increase the robustness of the inference. We argue for the paramount importance of extensive record keeping and reporting. Comparative studies struggle to balance technical properties with the need to obtain samples from multiple species. The authors argue for extensive record keeping and reporting of metadata to minimize the effect of confounders and increase the robustness of inferences from these studies.

中文翻译：

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比较功能基因组学的有效研究设计。

比较研究在平衡技术特性与从多个物种中获取样品的要求之间进行了挑战。需要准则以最大程度地减少混杂因素的影响并提高推断的鲁棒性。我们主张保持广泛的记录和报告至关重要。比较研究努力平衡技术特性与从多个物种获取样品的需求之间。作者主张进行大量的记录保存和元数据报告，以最大程度地减少混杂因素的影响并提高从这些研究中得出的推断的可靠性。