:Study Objective:To Evaluate the impact of mild-to-moderate orofacial tardive dyskinesia (TD) symptoms on the people and social lives of people with TD.Background:TD, a movement disorder affecting the face and extremities, may arise in patients taking antipsychotics. The impact of stigma on the professional and social lives of people with moderate-to-severe TD was previously examined, but has not been investigated in those with mild-to-moderate TD.Methods:This study is an experimental, randomized digital survey of a general population sample. Three component surveys corresponding to employment, dating, and friendship domains were adopted from a prior study. For each domain, participants were randomized 1:1 into either a test group (who viewed a video of a scripted interview with an actor depicting mild-to-moderate TD movements) or a control group (who viewed the same actor but without TD movements) and asked about their impressions of the video subject. Actor simulations of the TD symptoms were validated by physicians familiar with TD and rehearsed to simulate orofacial movements with a total Abnormal Involuntary Movement Scale (AIMS) score of 3–6. Statistical comparison was made using Wilcoxon signed-rank or chi-squared tests for continuous and categorical variables.Results:A total of 800 respondents completed each survey. In all domains, respondents had more negative perceptions of actors portraying mild-to-moderate TD movements than of the same actors without movements. For employment, 41% fewer respondents in the test group versus the control group agreed that the actor would be suitable for client-facing jobs (P<0.001). For dating, the proportions of respondents who agreed that they would like to continue talking to the actor and who would be interested in meeting them for a coffee/drink were 23.2% and 26.0% lower, respectively, in the test group than in the control group (P<0.001). For friendship, the proportions of respondents who rated the actor as interesting and who would be interested in friendship with them were 13.0% and 12.2% lower in the test group than in the control group (P<0.001).Conclusions:This study addresses the stigma faced by those with mild-to-moderate TD in professional and social situations. Consistent with previous results for moderate-to-severe TD, actors simulating mild-to-moderate orofacial TD movements were perceived to be less likely to move forward in a job interview, be considered as a potential romantic partner, or be a new friend.Funding Acknowledgements:This study was funded by Teva Pharmaceuticals, Petach Tikva, Israel.

中文翻译：

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115 一项评估轻度至中度迟发性运动障碍的专业和社会后果的实验研究

：研究目的：评估轻度至中度口面部迟发性运动障碍 (TD) 症状对 TD 患者的人和社会生活的影响。背景：TD 是一种影响面部和四肢的运动障碍，可能出现在服用以下药物的患者中抗精神病药。污名对中度至重度 TD 患者的职业和社会生活的影响之前已被研究过，但尚未在轻度至中度 TD 患者中进行调查。方法：本研究是一项实验性的随机数字调查一般人口样本。从先前的研究中采用了与就业、约会和友谊领域相对应的三个组成部分调查。对于每个领域，参与者被随机分配 1：1 到测试组（他们观看了描述轻度至中度 TD 动作的演员的脚本采访视频）或对照组（观看了同一演员但没有 TD 动作）并询问他们对视频的印象主题。TD 症状的演员模拟由熟悉 TD 的医生验证并排练以模拟口面部运动，总异常不自主运动量表 (AIMS) 得分为 3-6。使用 Wilcoxon 符号秩或卡方检验对连续变量和分类变量进行统计比较。结果：共有 800 名受访者完成了每次调查。在所有领域，与没有动作的相同演员相比，受访者对描绘轻度至中度 TD 动作的演员有更多的负面看法。为了就业，与对照组相比，测试组中的 41% 的受访者同意该演员适合面向客户的工作（P<0.001）。在约会方面，与对照组相比，测试组同意他们愿意继续与演员交谈以及有兴趣与他们会面喝咖啡/饮料的受访者比例分别低 23.2% 和 26.0%组（P<0.001）。在友谊方面，测试组认为演员有趣和对与他们建立友谊感兴趣的比例分别比对照组低 13.0% 和 12.2%（P<0.001）。轻度至中度 TD 患者在职业和社交场合面临的污名。与先前中度至重度 TD 的结果一致，